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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Therapeutic Efficacy of Nigella Sativa Linn. against Antituberculosis Drug−Induced Hepatic Injury in Wistar Rats

Volume 35, Numéro 1, 2016, pp. 59-71
DOI: 10.1615/JEnvironPatholToxicolOncol.2016013789
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RÉSUMÉ

Antituberculosis drug (ATD)-induced hepatotoxicity is a major impediment for the effective treatment of tuberculosis (TB). All first-line anti-TB medications have adverse effects that interrupt the successful completion of TB treatment. This investigation focuses on the evaluation of the protective role of Nigella sativa (NS) against liver injury caused by ATDs. Female rats were treated with ATDs for 8 weeks (3 d/wk) followed by NS for 8 weeks (3 d/wk). The antioxidant activity of NS was estimated with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and by analyzing total phenolic contents. Qualitative characterization of active compounds of the plant was done by high-performance liquid chromotography (HPLC). ATD-induced adverse effects were associated with sharp elevation in levels of serum transaminases, albumin, cholesterol, urea, uric acid, creatinine, and blood urea nitrogen (BUN). ATDs significantly increased lipid peroxidation (LPO) and decreased enzyme activities (superoxide dismutase [SOD], catalase [CAT], adenosine triphosphatase [ATPase], and glucose-6-phosphatase [G6Pase]) in liver, indicating oxidative stress. Conjoint treatment with NS could reverse the serological biochemistry and inhibit oxidative stress by suppressing LPO and augmenting antioxidant enzyme activity toward that of the control. Histological studies support the above biochemical findings. Results indicate that NS exerts excellent hepatoprotective abilities and can be used as a supplement to improve patient adherence and reduce interruptions in treatment due to ATD-related liver injury.

CITÉ PAR
  1. Uthra Chhavi, Shrivastava Sadhana, Jaswal Amita, Sinha Neelu, Reshi Mohd. Salim, Shukla Sangeeta, Therapeutic potential of quercetin against acrylamide induced toxicity in rats, Biomedicine & Pharmacotherapy, 86, 2017. Crossref

  2. Reshi Mohd Salim, Shrivastava Sadhana, Jaswal Amita, Sinha Neelu, Uthra Chhavi, Shukla Sangeeta, Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats, Experimental and Toxicologic Pathology, 69, 4, 2017. Crossref

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  4. Yang Miaomiao, Zhang Haiping, Tao Bilin, Pan Hongqiu, Lu Lihuan, Yi Honggang, Tang Shaowen, Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study, Journal of Clinical Pharmacy and Therapeutics, 44, 4, 2019. Crossref

  5. Akbar Shahid, Nigella sativa L. (Ranunculaceae), in Handbook of 200 Medicinal Plants, 2020. Crossref

  6. Reshi Mohd Salim, Yadav Deepa, Uthra Chhavi, Shrivastava Sadhana, Shukla Sangeeta, Acetaminophen-induced renal toxicity: preventive effect of silver nanoparticles, Toxicology Research, 9, 4, 2020. Crossref

  7. Ahmed Noor Zaheer, Agibothu Kupparam Hemanth Kumar, Akbar Seema, Hissar Syed, Anwar Noman, Thiruvengadam Kannan, Anjum Nighat, Khan Asim Ali, Dar Showkat, Natarajan Saravanan, Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats, Journal of Complementary and Integrative Medicine, 18, 3, 2021. Crossref

  8. Abo El‐Magd Nada F., El‐Mesery Mohamed, El‐Karef Amro, El‐Shishtawy Mamdouh M., Amelioration effect of black seed oil against high‐fat diet‐induced obesity in rats through Nrf2/HO‐1 pathway, Journal of Food Biochemistry, 45, 4, 2021. Crossref

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  11. Uthra Chhavi, Reshi Mohd Salim, Jaswal Amita, Yadav Deepa, Shrivastava Sadhana, Sinha Neelu, Shukla Sangeeta, Protective efficacy of rutin against acrylamide-induced oxidative stress, biochemical alterations and histopathological lesions in rats, Toxicology Research, 11, 1, 2022. Crossref

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