RT Journal Article
ID 5c50e40d27129bc9
A1 Leliebre-Lara, Vivian
A1 Pferschy-Wenzig, Eva-Maria
A1 Widowitz, Ute
A1 Ortmann, Sabine
A1 Lima, Clara Nogueiras
A1 Bauer, Rudolf
T1 Influence of Navisporus floccosus (Higher Basidiomycetes) n-Hexane Extract on Arachidonate Metabolism in Vitro
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2015
FD 2015-06-17
VO 17
IS 5
SP 463
OP 469
K1 medicinal mushrooms
K1 Navisporus floccosus
K1 anti-inflammatory
K1 cyclooxygenase
K1 leukotriene biosynthesis
AB In vitro anti-inflammatory activity of 4 extracts with different polarity from the basidiomycete Navisporus floccosus was evaluated by determination of the inhibition of prostaglandin E2 formation catalyzed by purified cyclooxygenase (COX)-1 and COX-2 enzymes, and of the inhibition of leukotriene (LT) B4 formation in human polymorphonuclear leukocytes. The n-hexane extract showed the highest activity in all 3 assays. Through analysis by gas chromatography coupled with mass spectrometry (GC-MS), 9 fatty acids and fatty acid esters were identified as the major constituents of this extract. As several of them also showed inhibitory activity in the COX and LTB4 formation assays, it can be assumed that the unsaturated as well as the saturated fatty acids, and maybe also the fatty acid esters, present in the extract synergistically contribute to its in vitro anti-inflammatory activity.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,118fb2a34500f533,5c50e40d27129bc9.html