RT Journal Article ID 4c54ef8600d258e0 A1 Putnam, D. A1 Doody, A. T1 RNA-Interference Effectors and Their Delivery JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2006 FD 2006-08-31 VO 23 IS 2 SP 137 OP 164 AB RNA-interference, the mechanism by which the expression of a specific protein can be reduced or eliminated, has emerged as a potential way to treat disease. RNA-interference effectors, such as small interfering RNA and small hairpin RNA, are double-stranded nucleic acid sequences expressly designed to have homology to sections of the target protein's mRNA, and when present in the cytosol trigger hydrolysis of the mRNA through the RNA-interference pathway. Because RNA-interference effectors are macromolecular and typically polyanionic, their efficacy is poor when not accompanied by a delivery vehicle. This review outlines the RNA-interference mechanism and discusses the delivery of RNA-interference effectors, with an emphasis on synthetic polymer-based delivery systems. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,2c7ebfdd101fd750,4c54ef8600d258e0.html