%0 Journal Article %A Chien, Rao-Chi %A Lin, Lan-Min %A Chang, Yuan-Hua %A Lin, Yu-Chieh %A Wu, Pei-Hsuan %A Asatiani, Mikheil D. %A Wasser, Sophie-Gabrielle %A Krakhmalnyi, Maxim %A Agbarya, Abed %A Wasser, Solomon P. %A Mau, Jeng-Leun %D 2016 %I Begell House %K flavonoids, fruiting body, inflammation, medicinal mushrooms, mycelium, phenols %N 11 %P 999-1009 %R 10.1615/IntJMedMushrooms.v18.i11.50 %T Anti-Inflammation Properties of Fruiting Bodies and Submerged Cultured Mycelia of Culinary-Medicinal Higher Basidiomycetes Mushrooms %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,07a0495239bddf76,4ba191eb4578ed4d.html %V 18 %X This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts. Overall, Cordyceps militaris fruiting bodies, Grifola frondosa fruiting bodies, and Ophiocordyceps sinensis mycelia might be used to ameliorate inflammatory responses. %8 2016-12-20