RT Journal Article
ID 4b5994521758a911
A1 Engelmann, Swen 
A1 Togni, Mauro 
A1 Kliche, Stefanie 
A1 Reinhold, Dirk 
A1 Schraven, Burkhart 
A1 Reinhold, Annegret
T1 The Adhesion- and Degranulation-Promoting Adaptor Protein and Its Role in the Modulation of Experimental Autoimmune Encephalomyelitis
JF Critical Reviews™ in Immunology
JO CRI
YR 2015
FD 2015-02-20
VO 35
IS 1
SP 1
OP 14
K1 EAE
K1 CNS
K1 autoimmunity
K1 adaptor protein
K1 ADAP
AB Adaptor proteins mediate protein−protein interactions in signal transduction cascades. These signaling molecules are organized in multimolecular complexes that translate information from cell surface receptors into cellular responses. The cytosolic adhesion- and degranulation-promoting adaptor protein (ADAP) is expressed in T cells, natural killer cells, myeloid cells, and platelets. Here we summarize the data about the function of ADAP in these cells with respect to their contribution to the pathogenesis of experimental autoimmune encephalomyelitis. We discuss possible mechanisms of strongly attenuated experimental autoimmune encephalomyelitis in ADAP-deficient mice.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,59d3fecb4dbb6d4a,4b5994521758a911.html