RT Journal Article
ID 462ce3ab292100c7
A1 Ng, Tzi Bun
A1 Wang, Hexiang
A1 Wan, D. C. C.
T1 Polysaccharopeptide from the Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilát Inhibits Human Immunodeficiency Virus Type 1 Reverse Transciptase and Protease
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2006
FD 2006-04-25
VO 8
IS 1
SP 39
OP 43
AB Polysaccharopeptide from the Turkey Tail fungus Trametes (=Coriolus) versicolor has been reported to possess a number of important attributes including anticancer, immunomodulatory, analgesic, and hepatoprotective activities. In this investigation, it is shown that the polysaccharopeptide is capable of inhibiting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease, the two enzymes of paramount importance to the life cycle of the HIV. The polysaccharopeptide inhibits other proteases including trypsin, α-chymotrypsin, proteinase K, subtilisin, and elastase to a smaller extent. The anti-HIV enzyme and immunostimulatory activities of the mushroom polysaccharopeptide make it a potential candidate for the therapy of AIDS.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,004dba6c170c81d1,462ce3ab292100c7.html