RT Journal Article
ID 38e8285f7b4e4ba2
A1 Xu, Xin
A1 Pang, Chong
A1 Yang, Chengjian
A1 Zheng, Yitong
A1 Xu, Hong-Yu
A1 Lu, Zhenming
A1 Xu, Zheng-Hong
T1 Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2010
FD 2010-08-24
VO 12
IS 3
SP 235
OP 244
K1 medicinal mushrooms
K1 polysaccharides
K1 antihyperglycemic
K1 antilipidperoxidative
K1 antioxidant
K1 diabetes
K1 chaga mushroom
K1 Inonotus obliquus
AB The optimum conditions for the extraction of crude polysaccharides from dry matter of culture broth (DMCB) of Inonotus obliquus were determined by using response surface methodology (RSM). In alloxan-induced diabetic mice, treatment with polysaccharide extract from DMCB of I. obliquus (150 and 300 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, with percentage reductions of 16.64% and 20.09% at the 7th day, and 29.71% and 36.36% at the 21st day, respectively. Furthermore, polysaccharide treatment significantly decreased serum contents of free fatty acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol, whereas it effectively increased high-density lipoprotein cholesterol, insulin levels, and hepatic glycogen contents in the liver of diabetic mice. In addition, the polysaccharides significantly increased catalase, superoxide dismutase, and glutathione peroxidase activities, whereas they decreased the maleic dialdehyde level in diabetic mice. A histological morphology examination showed that the polysaccharides restored the damage of pancreatic tissues in mice with diabetes mellitus. The results revealed that the I. obliquus polysaccharides possessed antihyperglycemic, antilipidperoxidative, and antioxidant effects in alloxan-induced diabetic mice.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2da9c44d295f30f8,38e8285f7b4e4ba2.html