RT Journal Article ID 388a94587c62a532 A1 Kotreka, Udaya A1 Adeyeye, Moji Christianah T1 Gastroretentive Floating Drug-Delivery Systems: A Critical Review JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2011 FD 2011-03-10 VO 28 IS 1 SP 47 OP 99 K1 gastric physiology; gastric retention; effervescent systems; buoyancy; dissolution; scintigraphy; imaging; holt-melt extrusion; melt pelletization AB The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, gastroretentive systems such as mucoadhesive, high-density, expandable, and floating systems have been developed. These systems provide controlled delivery of drugs with prolonged gastric residence time. However, in humans, differences in various physiological and biological factors can affect the gastric residence time and drug-delivery behavior from gastroretentive systems. Some floating drugdelivery systems (FDDS) have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses on various physiological considerations for development of FDDS, and highlights recent technological developments including new dosage forms and their production techniques (e.g., holt-melt extrusion, melt pelletization, and pulsed plasma-irradiation processes). Alternatives to the existing in vitro compendial methods for evaluating floating dosage forms will be discussed, and a critical analysis of the existing literature on FDDS, identifying the potential areas for future research, is provided. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,236653ac2a7387a4,388a94587c62a532.html