RT Journal Article ID 36a57ffe25f4903b A1 Coquery , Christine M. A1 Erickson, Loren D. T1 Regulatory Roles of the Tumor Necrosis Factor Receptor BCMA JF Critical Reviews™ in Immunology JO CRI YR 2012 FD 2012-12-12 VO 32 IS 4 SP 287 OP 305 K1 BCMA; BAFF; APRIL; B cells; plasma cells; autoimmunity AB B cell maturation antigen (BCMA) is a tumor necrosis family receptor (TNFR) member that is predominantly expressed on terminally differentiated B cells and, upon binding to its ligands B cell activator of the TNF family (BAFF) and a proliferation inducing ligand (APRIL), delivers pro-survival cell signals. Thus, BCMA is mostly known for its functional activity in mediating the survival of plasma cells that maintain long-term humoral immunity. The expression of BCMA has also been linked to a number of cancers, autoimmune disorders, and infectious diseases that suggest additional roles for BCMA activity. Despite recent advances in our understanding of the roles for the related TNFR members BAFF-R and transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), the signaling pathway used by BCMA for mediating plasma cell survival as well as its putative function in certain disease states are not well understood. By examining the expression, regulation, and signaling targets of BCMA, we may gain further insight into this receptor and how it operates within cells in both health and disease. This information is important for identifying new therapeutic targets that may be relevant in treating diseases that involve the BAFF/APRIL cytokine network. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,3348358a38f6810f,36a57ffe25f4903b.html