RT Journal Article ID 2d412f781857fc4e A1 Qadir, Muhammad Imran A1 Anwar, Sidra T1 Sirtuins in Brain Aging and Neurological Disorders JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 2017 FD 2017-12-18 VO 27 IS 4 SP 321 OP 329 K1 aging K1 metabolic regulation K1 brain aging K1 Sir2 K1 SIRT1 K1 SIRT3 K1 calorie restriction AB The many ways of aging have been and continue to be investigated. For this reason, over many years, several studies have resolved some of the genetic details underlying aging processes. It resulted in the identification of a yeast gene known as Sir2, which is a longevity modulator. Sir2 and SIRT1 are the mammalian homologs of yeast genes. Sirtuins (including SIRT1) play an important role in aging of the brain and the metabolic regulation pathway in mammals. Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration. The sirtuin family plays a central role in the beneficial effects of calorie restriction (CR). CR is linked with an increase in life span and decrease in the risk of diseases related to the brain. Sirtuins may be helpful for us in studying the process of aging and treatment of diseases related with aging. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,472346f663f7f2e2,2d412f781857fc4e.html