RT Journal Article ID 12b6fd5d064052c8 A1 O'Connor, P. J. A1 MacNaught, F. A1 Butler, W. H. A1 Cooper, D. P. A1 Margison, G. P. A1 Povey, A. C. T1 Increased Pathology Incidence in the Forestomach of Rats Maintained on a Diet Containing Ivermectin and Given a Single Dose of N-Methyl-N1-Nitro-N-Nitrosoguanidine JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2001 FD 2001-09-01 VO 20 IS 3 OP 5 AB Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) bygavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the fore-stomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,4f3d49236da6f09c,12b6fd5d064052c8.html