%0 Journal Article
%A Wang, Junzhi
%A Lv, Huifang
%A Chen, Beiyan
%A Huang, Wenfeng
%A Wang, Ailing
%A Liu, Lanqing
%A He, Haibo
%A Chen, Jianfeng
%A Li, Shi
%A Deng, Wei-Qiao
%D 2019
%I Begell House
%K methyl-hispolon, estrogen signals, phytoestrogen, hormone replacement therapy, Phellinus lonicerinus, medicinal mushrooms
%N 4
%P 381-392
%R 10.1615/IntJMedMushrooms.2019030355
%T Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats
%U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,2b9ba90674ebcc50,0092270b77a07187.html
%V 21
%X We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6.68 kcal/mol in docking simulations. Methyl-hispolon had a significant antiproliferative effect for estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen, and it exhibited dual estrogen activities. Methyl-hispolon increased the serum E2 in rats with premature ovarian failure and fulfilled the estrogenic function in the uterus and ovary. Methyl-hispolon significantly inhibited the expression of Ras, API, ERα, C-myc, and cyclinDl, as well as their gene transcription in RL95-2 cells. The phosphorylation of ERK1/2 was inhibited by methyl-hispolon. Thus, methyl-hispolon has potential use in treating estrogen deficiency-related diseases, with good antitumor effects and estrogenic activity.
%8 2019-04-11