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Critical Reviews™ in Neurobiology

Publicado 3 números por año

ISSN Imprimir: 0892-0915

ISSN En Línea: 2375-0014

SJR: 0.121

5-Lipoxygenase as a Putative Link Between Cardiovascular and Psychiatric Disorders

Volumen 16, Edición 1&2, 2004, pp. 181-186
DOI: 10.1615/CritRevNeurobiol.v16.i12.190
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SINOPSIS

There is evidence of an association between depression and anxiety and cardio— cerebro—vascular conditions, but the mechanisms of this association are unknown. Here we review a possible role for the 5-lipoxygenase (5-LOX) pathway. 5-LOX is an enzyme that, in association with 5-LOX-activating protein (FLAP), leads to the synthesis of leukotrienes from omega-6 arachidonic acid. Production of active leukotrienes can be reduced by dietary omega-3 fatty acids, which also are beneficial in cardiac and psychiatric (e.g., depression) pathologies. Human 5-LOX and FLAP gene polymorphisms are a risk factor in atherosclerosis and cardio—cerebro—vascular pathologies; an overactive 5-LOX pathway is found in these diseases. Studies with 5-LOX-deficient transgenic mice suggest that 5-LOX activity may contribute to anxiety- and depression-like behaviors. Future research should characterize the role of the 5-LOX pathway in comorbid cardio—cerebro—vascular and psychiatric disorders and in the therapeutic actions of dietary omega-3 fatty acids

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