Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i6.20
pages 505-511

Developmental Toxicity Assessment of Medicinal Mushroom Antrodia cinnamomea T.T. Chang et W.N. Chou (Higher Basidiomycetes) Submerged Culture Mycelium in Rats

Tai-I Chen
Grape King Inc., 60 Sec. 3, Lung-Kang Rd, Chung-Li City 320, Taiwan
Chiao-Wen Chen
Development Center for Biotechnology, 101 Lane 169, Kang-Ning St., Xizhi District, New Taipei City 221, Taiwan
Ting-Wei Lin
Grape King Biotechnology Inc., Chung-Li City, Taiwan
Di-Sheng Wang
Development Center for Biotechnology, 101 Lane 169, Kang-Ning St., Xizhi District, New Taipei City 221, Taiwan
Chin-Chu Chen
Bioengineering Center, Grape King Bio Ltd, Taoyuan City, Taiwan; Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei City, Taiwan; Institute of Biotechnology, National Changhua University of Education, Changhua County, Taiwan


Antrodia cinnamomea is a Taiwanese medicinal mushroom with high antioxidant and polysaccharide content. The objective of this study is to investigate developmental toxicity of A. cinnamomea in pregnant Sprague-Dawley rats. Animals were daily gavaged with A. cinnamomea mycelium at dosage levels of 0 (reverse osmosis water), 50, 150, and 500 mg/kg from gestation day (GD) 6 to 15. All dams were sacrificed on GD 20 and were subjected to cesarean section. Fetuses were examined for external, visceral, and skeletal abnormalities. All copulated females survived until the end of the study. No significant differences were recorded in body weight change, food consumption, and maternal gestational parameters. Only two fetal malformations were noted in 970 fetuses from the treatment groups. Some variations, such as enlarged fontanel, split sternebrae, absent sacral, absent caudal vertebral centra, absent thoracic centra, absent 13th−14th ribs, and fused ribs, were found during the skeletal examination, but no treatment-induced abnormalities occurred. No dose dependency was observed in any of the developmental variations. Overall observation of foetal malformations from rats given A. cinnamomea mycelium during pregnancy demonstrates that this material is not teratogenic at doses up to 500 mg/kg. It is concluded that A. cinnamomea BCRC 35398 mycelium has no teratogenic effects in female rats and is safe to be used as a functional food ingredient.

Articles with similar content:

Reproductive and Developmental Toxicity Evaluation of Desoris (LLL 3348) in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 4
Salim Tamboli, Gururaj Vishwase, Sudershan Arora, Upendra Bhatnagar
Oral Hypoglycemic Activity of Culinary-Medicinal Mushrooms Pleurotus ostreatus and P. cystidiosus (Higher Basidiomycetes) in Normal and Alloxan-Induced Diabetic Wistar Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 4
C.A. Wanigatunga, W.J.A.B.N. Jayasuriya, T.S. Suresh, G.H. Fernando, D. Thusitha U. Abeytunga
Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
Pradeep Kumar Goyal, Archana Jindal, Annapurna Agrawal
A 90-Day Subchronic Toxicity Study of Submerged Mycelial Culture of Cordyceps cicadae (Ascomycetes) in Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 8
Shu-Hsing Yeh, Ting-Wei Lin, Chin-Shuh Chen, Yen-Lien Chen, Chin-Chu Chen, Chia-Feng Kuo
Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 12
Yan-Feng Xu