Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i3.10
pages 209-218

Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice

Katarzyna Socala
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Dorota Nieoczym
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Krzysztof Grzywnowicz
Department of Biochemistry, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Dawid Stefaniuk
Department of Biochemistry, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland
Piotr Wlaz
Department of Animai Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Akademicka 19, Lublin, Poland

SINOPSIS

Ganoderma lucidum is a well-known medicinal mushroom with a long history of use. This study was designed to assess the anticonvulsant potential of an aqueous extract from cultured G. lucidum mycelium in 3 acute seizure models: timed intravenous pentylenetetrazole infusion, maximal electroshock seizure threshold, and 6-Hz-induced psychomotor seizure tests in mice. Moreover, antidepressant-like and anxiolytic-like effects of G. lucidum were evaluated using the forced swim test and the elevated plus maze test in mice, respectively. No changes in seizure thresholds in the intravenous pentylenetetrazole and maximal electroshock seizure threshold tests after acute treatment with G. lucidum extract (200−600 mg/kg) was observed. However, the studied extract (100−400 mg/kg) significantly increased the threshold for psychomotor seizures in the 6-Hz seizure test. In the forced swim test, G. lucidum (100−400 mg/kg) significantly reduced the duration of immobility. No anxiolytic-like or sedative effects were reported in mice pretreated with the extract (400−600 mg/kg). G. lucidum extract (50−2400 mg/kg) did not produce toxic effects in the chimney test (motor coordination) or grip-strength test (neuromuscular strength). Further studies are required to explain the neuropharmacological effects of G. lucidum and to identify its active ingredients that may affect seizure threshold, mood, or anxiety.


Articles with similar content:

Lyophilized Extract of the Horse Mushroom, Agaricus arvensis (Agaricomycetes), Delays Erythrocyte Hemolysis and Stabilizes Some Blood Parameters in Carbon Tetrachloride-Intoxicated Rats
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 10
Abdulahad Dogan
Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), Demonstrated Antiepileptic Activity against Seizure Induced by Maximal Electroshock and Isoniazid in Experimental Animals
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 1
Rajendra Awasthi, Gaurav Gupta, Rakesh Kumar Sharma, Kamal Dua, Rajiv Dahiya, Sachchidanand Pathak, Mohit Agrawal, Anurag Mishra
Protective Effects of Picorrhiza Kurroa Extract against 2-Acetylaminofluorene-Induced Hepatotoxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Sarwat Sultana, Sahar Rahman
Carotenoid Lutein Protects the Kidney against Cisplatin-Induced Acute Renal Failure
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Ramadasan Kuttan, Edakkadath Raghavan Sindhu
Modulation of Rat Myometrium Contractile Activity by Peptidocycan of Staphfylococcus Aureus Cell Wall
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 4
Igor B. Philyppov, Lilit S. Nasibyan