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International Journal of Medicinal Mushrooms
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ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i3.40
13 pages

Hypoglycemic, Interferonogenous, and Immunomodulatory Activity of Tremellastin from the Submerged Culture of Tremella mesenterica Retz.: Fr. (Heterobasidiomycetes)

Vladimir I. Elisashvili
Animal Husbandry and Feed Production Institute of Agricultural University of Georgia, 240 David Agmashenebeli alley, 0159 Tbilisi, Georgia
Solomon P. Wasser
N.G. Kholodny Institute of Botany, NAS of Ukraine, 2 Tereshchenkovskaya Str., Kiev 01004, Ukraine; International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mount Carmel, Haifa, Israel
Kok- Kheng Tan
MycoBiotech Pte Ltd 12 Science Park Drive # 04-01 The Mendel- Singapore Science Park 1 118 225, Singapore


Tremellastin, containing 40-45% acidic polysaccharide glucuronoxylomannan, was obtained by alcohol precipitation of culture broth after submerged cultivation of a yeastlike budding haploid strain of Tremella mesenterica. Tremellastin at a dose of 100 mg/kg and 500 tng/kg by P.O. administration during 15 consecutive days did not demonstrate hypoglycemic effects on the basis of the two selected experimental models of glucose-loading and STZ-induced hyperglycemia. However, the findings show a statistically significant and dose-dependent reduction of intrinsic blood glucose levels after 15 treatment days, as well as significantly decreased triglyceride levels in the glucose-loading-assigned Tremellastin-treatment groups. It was shown that the Tremellastin preparation appeared to be an active interferonogen at the concentration 10 mg/animal. At the same concentration this compound was the most efficient activator of oxygen-dependent biocide activity of macrophages. The activation of the oxygen-dependent macrophage biocide activity was associated with the induction of endogenous interferon by Tremellastin.

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