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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i2.30
pages 145-152

Purification and Characterization of a Novel Small-Molecule Polysaccharide from the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes)

Changyan Zhou
Shanghai Jiao Tong University, School of Agriculture and Biology, Shanghai, China; Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China
Yanru Qiao
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, China; College of Pharmaceutical Sciences, Southwest University, Chongqing, China
Qingjiu Tang
Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China
Wei Jia
National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, P.R. China
Yanfang Liu
National Engineering Research Centre of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilisation, Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agriculture Sciences, Shanghai, People's Republic of China
Aizhong Wu
Shanghai Jiao Tong University, School of Agriculture and Biology, Shanghai, China; Institute for Agri-food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai, China

SINOPSIS

A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifola frondosa. GFPS is composed of fucose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides. Absorption peaks at 1077 cm−1, 1024 cm−1, and 873 cm−1, as revealed by infrared spectrum, suggesting that GFPS consists of pyranoside. GFPS significantly enhanced the production of nitric oxide and secretion of cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-δ) from macrophages in vitro. These results indicate that this novel small-molecule polysaccharide might be beneficial for immune defense.


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