Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i4.10
pages 319-326

Supplementation with a Soluble Beta-Glucan Exported from Shiitake Medicinal Mushroom, Lentinus edodes (Berk.) Singer Mycelium: a Crossover, Placebo-Controlled Study in Healthy Elderly

Jean-Michel Gaullier
Link Medical Research AS, POBox 4382 Nydalen, 0402 Oslo, Norway
Jowita Sleboda
Link Medical Research AS, POBox 4382 Nydalen, 0402 Oslo, Norway
Erik Snorre Ofjord
CENCLIN, Gamlehaugsveien 20, N-5231 Paradis, Norway
Elling Ulvestad
Laboratory of Microbiology and Immunology, Haukeland hospital, N-5021 Bergen, Norway
Minna Nurminiemi
Link Medical Research AS, POBox 4382 Nydalen, 0402 Oslo, Norway
Cecilie Moe
Link Medical Research AS, POBox 4382 Nydalen, 0402 Oslo, Norway
Tor Albrektsen
Ola Gudmundsen
Link Medical Research AS, POBox 4382 Nydalen, 0402 Oslo, Norway


Lentinus edodes (Shiitake) is a medicinal mushroom with a long tradition of use in Asia. The major active substance in L. edodes is a (1-6,1-3)-beta-glucan (lentinan). No clinical controlled studies have yet investigated the effect of orally administered lentinan on the immune response in healthy, elderly Caucasian subjects. We evaluated the effect and the safety of a beta-glucan from L. edodes mycelium, Lentinex®, in healthy, elderly subjects in a double blind, crossover, placebo-controlled trial. Forty-two subjects were randomly allocated to two groups given orally either 2.5 mg/day Lentinex® or placebo for 6 weeks; then after a washout period of 4 weeks, the alternate supplementation was given for 6 weeks. The changes in the number of B-cells were significantly different between the groups. The number of NK cells increased significantly in both groups, but there was no significant difference between the groups. Other factors of the immune response (immunoglobulins, complement proteins, cytokines) were not altered. The safety blood variables (differential cell count, liver function, kidney function, and other blood chemistry) were not influenced by Lentinex®, and the number, nature, and severity of adverse events were similar to placebo. Lentinex® given orally to elderly subjects was safe and induced an increase in the number of circulating B-cells.

Articles with similar content:

Serum Testosterone Levels in Statin Therapy for Patients with Diabetes and Hypertension
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Anuradha Argi, Jagannadha Rao Peela, Azhar Hussain, Aaren Vedangi, Shakila Srikumar, Ahmed M. Zakoko, Yupa Min , Dawoodi Fakruddin, Wahid M. El Sheriff, Abdalla Mohammed Jarrari, Mohammed G. Elfturi, Sara A. Shoaib, Laxmi Teja Peela, Avinash K. Rawal, Noah Mohammed Hamed Aljarari
Combination Therapy of Transplanted Meth-A Fibrosarcoma in BALB/c Mice with Protein-Bound Polysaccharide EA6 Isolated from Enokitake Mushroom Flammulina velutipes (W.Curt.:Fr.)Singer and Surgical Excision
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Tetsuro Ikekawa, Hirofumi Maruyama
Immunomodulating Activity of a b-Glucan Preparation, SCG, Extracted from a Culinary–Medicinal Mushroom, Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae), and Application to Cancer Patients
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Hitoji Yoshida, Yoshiyuki Adachi, Noriko N. Miura, Sachiko Nameda, Toshiro Yadomae, Mitsuhiro Nakajima, Naohito Ohno, Kenshi Yoshida, Toshie Harada
High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 1
Raffaello Di Bernardi, Rosalia Rubel, Jose Hermenio Cavalcante Lima Filho, Carlos Ricardo Soccol, Luiz Claudio Fernandes, Andrea N. Moreno, Fan Leifa, Herta Stutz Dalla Santa, Bonald Cavalcante Figueiredo
Influence of Nigerian Jelly Ear Culinary−Medicinal Mushroom, Auricularia auricula-judae (Agaricomycetes), on Humoral and Cellular Immunity
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 5
Malachy Ugwu , Stella Amarachi Ihim, Moses Ikegbunam , Chukwuemeka Sylvester Nworu, Veronica Ibe