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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018029737
pages 193-203

Safety Evaluation of an Aqueous Extract of Termitomyces robustus (Agaricomycetes) in Wistar Rats

Eziuche Amadike Ugbogu
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria
Emmanuel Iroha Akubugwo
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria
Victor Chibueze Ude
Department of Medical Biochemistry, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria
Okezie Emmanuel
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria
Nduka Ozoji Okomba
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria
Cynthia Ibe
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria
Ozioma Onyero
Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria

SINOPSIS

Termitomyces robustus is an edible and highly nutritious wild Basidiomycetes mushroom. It is used in ethnomedicine for treating malnutrition-related diseases, rheumatism, diarrhea, gonorrhea, anemia, and hypertension. Despite the tremendous use of this delicious edible mushroom as a source of nutrients, no comprehensive literature describes its safety and toxicity profiles. Therefore, this study evaluated the toxicity profile of an aqueous T. robustus extract in rats. In the acute toxicity test, male and female rats were orally administered daily a single dose of up to 10 g/kg extract. In the subacute toxicity test, male rats were orally administered the T. robustus extract at graded doses of 500, 1000, and 1500 mg/kg for 14 days. No mortality or any signs of toxicity were observed in the acute toxicity study, indicating that the median lethal dose (LD50) of T. robustus is greater than 10 g/kg. In the subacute toxicity study, T. robustus had no effect (P > 0.05) on hemoglobin, packed cell volume, red blood cell, white blood cell, alanine aminotransferase, alkaline phosphatase, neutrophil, lymphocyte, or lipid profile parameters in any of the rats. However, significant differences (P < 0.05) were noted in alanine aminotransferase, eosinophils, basophils, monocytes, platelets, urea, creatinine, and electrolytes in the tested groups when compared to values from the control group. No histopathological alterations or changes were observed in the liver or kidneys of the rats. This study established that an aqueous extract of T. robustus is nontoxic and therefore safe for consumption at the tested doses.


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