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International Journal of Medicinal Mushrooms
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ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018027389
pages 849-858

Immunomodulatory Effects of the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes)-Based Health Food Product in Mice

Yu-Hsing Lin
Taiwan Leader Biotech Corp, Taipei, Taiwan
Jong-Tar Kuo
Department of Biological Science and Technology, China Medical University of Science and Technology, Taipei, Taiwan
Yun-Yu Chen
Taiwan Leader Biotech Corp, Taipei, Taiwan
K. J. Senthil Kumar
Department of Forestry, National Chung Hsing University, Taichung, Taiwan
Chiu-Ping Lo
Taiwan Leader Biotech Corp, Taipei, Taiwan
Chin-Chung Lin
Taiwan Leader Biotech Corp, Taipei, Taiwan
Sheng-Yang Wang
Department of Forestry, National Chung Hsing University, Taichung, Taiwan; Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan


Taiwanofungus camphoratus is a unique medicinal mushroom endemic to Taiwan, and it is used as a folk medicine in East Asian countries. The aim of the present study was to investigate the immunomodulatory effects of "leader Antrodia cinnamomea capsule" (LAC), a health food product containing solid-state cultivated mycelial powder of T. camphoratus. For the in vivo studies, mice were orally administered LAC (76, 250, and 760 mg/kg b.w.) for 30 days, and its effects on cell-mediated humoral immune function were examined. The results of the concanavalin A-induced splenic lymphocyte proliferation test showed that LAC significantly increased splenic lymphocyte proliferation compared with the control. In addition, serum hemolysin analysis showed that LAC treatment significantly increased the half value of serum hemolysin (HC50) in mice compared with the control. Moreover, treatment with LAC significantly increased the phagocytic index as measured by carbon clearance and natural killer cell activity. Taken together, these findings provide strong evidence that LAC can modulate immune function.

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