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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Antinociceptive Activity of Agaricoglycerides Extracted from Mycelium of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)

Volumen 12, Edición 3, 2010, pp. 273-278
DOI: 10.1615/IntJMedMushr.v12.i3.60
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SINOPSIS

The antinociceptive activity of agaricoglycerides extracted from mycelium of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum (AMG) was studied. The writhing test, formalin test, and hot-plate test, as well as the in vitro neurolysin inhibition assay, were respectively used to evaluate the antinociceptive activity of agaricoglycerides. The extracted agaricoglycerides inhibited acetic acid-induced abdominal constrictions in mice in a dose-dependent manner (P < .05). Both phases of response to the formalin test were also significantly inhibited (P < .05). The results from the hot-plate test showed that the extract significantly (P < .05) inhibited the reaction time to thermal stimuli at 30, 60, and 90 min after application. In the neurolysin inhibition assay, AMG showed strong activities against neurolysin (IC50 = 100 nM). Our results indicate that if the same effects in humans or higher animals are shown, AMG may have potential applications as a component of analgesic food/ feed and possibly even as a medicine.

CITADO POR
  1. Han Chuncho, Cui Bo, Pharmacological and Pharmacokinetic Studies with Agaricoglycerides, Extracted from Grifola frondosa, in Animal Models of Pain and Inflammation, Inflammation, 35, 4, 2012. Crossref

  2. Zhang Lan, Yuan Bo, Wang HuiPing, Gao Ya, Therapeutic Effect ofAgaricus brasiliensison Phenylhydrazine-Induced Neonatal Jaundice in Rats, BioMed Research International, 2015, 2015. Crossref

  3. Zhao Xiang-qian, Liang Bin, Liu Yang, Huang Xiao-qiang, Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB, Evidence-Based Complementary and Alternative Medicine, 2015, 2015. Crossref

  4. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  5. Wang Yuxiao, Shi Xiaodan, Yin Junyi, Nie Shaoping, Bioactive polysaccharide from edible Dictyophora spp.: Extraction, purification, structural features and bioactivities, Bioactive Carbohydrates and Dietary Fibre, 14, 2018. Crossref

  6. Wang Yuxiao, Huang Xiaojun, Nie Shaoping, Mushrooms: Isolation and Purification of Exopolysaccharides, in Biology of Macrofungi, 2018. Crossref

  7. Ren Jun, Shi Jin-Li, Han Chun-Chao, Liu Zhen-Quan, Guo Jian-You, Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus , BMC Complementary and Alternative Medicine, 12, 1, 2012. Crossref

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