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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Mycelium Aqueous Extract Modulates High-Altitude–Induced Stress

Volumen 21, Edición 5, 2019, pp. 443-458
DOI: 10.1615/IntJMedMushrooms.2019030648
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SINOPSIS

Environmental adversities such as high altitudes impair human performance and under such environmental threats, adaptogens tend to enhance physical endurance, mental functions, and nonspecific resistance of the body. Herein, adaptogenic activity of the medicinal mushroom Ganoderma lucidum (mycelium aqueous extract; GLMaq) was evaluated by exposing rats to cold (5°C), hypoxia (428 mm Hg), and a restraint state. GLMaq was administered orally at 50, 100, and 150 mg/kg body weight (bw) and rats were fasted overnight before exposure. After exposure, antioxidant and stress markers (catalase, lactate dehydrogenase, lipid peroxidation, reduced glutathione, and superoxide dismutase levels) were investigated in tissue homogenates (liver, heart, and skeletal muscle) along with hematological parameters. Mitochondrial morphology was observed by transmission electron microscopy in skeletal muscles. Biodistribution study for technetium-99m–labeled GLMaq was determined in mice in blood and major organs (heart, intestine, kidney, liver, lungs, muscle, spleen, and stomach). Antioxidants (ascorbic acid, gallic acid, rutin, and quercetin) were quantified by ultra-performance liquid chromatography. In vitro free radical scavenging activities were also determined. A 100 mg/kg bw dose was found to be relatively effective as measured by time taken to reach rectal temperature (Trec) 23°C; however, the 50 mg/kg bw dose showed significant results as observed from biochemical parameters for liver, heart, and skeletal muscle. The current study suggested the potential use of GLMaq as an adaptogenic agent against high-altitude–induced stress; this is further supported by a wide distribution of technetium-99m radiolabeled G. lucidum mycelium aqueous extract to various organs and protective effects of GLMaq against mitochondrial impairment by maintaining mitochondrial number and morphology.

CITADO POR
  1. Hu Ting, Lei Yue, Li Minxue, Liu Qin, Song Li, Zhao Degang, Dietary Eucommia ulmoides Extract Alleviates the Effect of Cold Stress on Chick Growth Performance, Antioxidant and Immune Ability, Animals, 11, 11, 2021. Crossref

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