Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i5.60
pages 463-469

Influence of Navisporus floccosus (Higher Basidiomycetes) n-Hexane Extract on Arachidonate Metabolism in Vitro

Vivian Leliebre-Lara
Centre for Natural Product Studies, Faculty of Chemistry, University of Havana; Havana, Cuba
Eva-Maria Pferschy-Wenzig
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Ute Widowitz
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Sabine Ortmann
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz; Graz, Austria
Clara Nogueiras Lima
Centre for Natural Product Studies, Faculty of Chemistry, University of Havana; Havana, Cuba
Rudolf Bauer
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, 8010 Graz, Austria

SINOPSIS

In vitro anti-inflammatory activity of 4 extracts with different polarity from the basidiomycete Navisporus floccosus was evaluated by determination of the inhibition of prostaglandin E2 formation catalyzed by purified cyclooxygenase (COX)-1 and COX-2 enzymes, and of the inhibition of leukotriene (LT) B4 formation in human polymorphonuclear leukocytes. The n-hexane extract showed the highest activity in all 3 assays. Through analysis by gas chromatography coupled with mass spectrometry (GC-MS), 9 fatty acids and fatty acid esters were identified as the major constituents of this extract. As several of them also showed inhibitory activity in the COX and LTB4 formation assays, it can be assumed that the unsaturated as well as the saturated fatty acids, and maybe also the fatty acid esters, present in the extract synergistically contribute to its in vitro anti-inflammatory activity.


Articles with similar content:

Hepatoprotective Effect of Auricularia delicata (Agaricomycetes) from India in Rats: Biochemical and Histopathological Studies and Antimicrobial Activity
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 3
Geeta Devi Leishangthem, Devi Datt Joshi, Sujata Devi Wangkheirakpam, Lokesh Deb, Dipak Biswas
Chemical Composition and Medicinal Value of the New Ganoderma tsugae var. jannieae CBS-120304 Medicinal Higher Basidiomycete Mushroom
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 8
Solomon P. Wasser, Lital E. Sharvit, Mikheil D. Asatiani, Gayane S. Barseghyan, Jannie Siew Lee Chan, Beny Trabelcy
Antioxidative and Inhibitory Effects of the Fruiting Body of Black Lingzhi Mushroom, Amauroderma rugosum (Agaricomycetes), on LDL Oxidation and HMG-CoA Reductase Activity
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Norhaniza Aminudin, Noorlidah Abdullah, Chan Kam Seng
The Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) Substances Interfere with H2O2 Induction of the NF-κB Pathway through Inhibition of IκBα Phosphorylation in MCF7 Breast Cancer Cells
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 1
Solomon P. Wasser, Nili Ruimi, Abraham Reznick, Mikheil D. Asatiani, Eviatar D. Nevo, Jamal A. Mahajna
Bioactivity-Guided Isolation of Acetylcholinesterase Inhibitor from Ganoderma mediosinense (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 8
Arshdeep Kaur, Kudrat Randhawa, Varinder Singh, Richa Shri