Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v2.i4.130
10 pages

Neurotropic Effect of Extracts from the Hallucinogenic Mushroom Psilocybe cubensis (Earle) Sing. (Agaricomycetideae). In Vitro Studies

Mykhaylo Moldavan
Oregon Health and Science University
Elvira F. Solomko
M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Kiev, Tereshchenkivska Str. 2, GSP, 01601, Ukraine
Anna A. Grodzinskaya
Department of Spore Plants, M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Tereshchenkivska str. 2, Kiev, GSP-1, 01601, Ukraine
Victor M. Storozhuk
Department of Brain Physiology, A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Bogomoltza str. 4, Kiev 01024
Marharyta L. Lomberg
M. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, Kiev, Tereshchenkivska Str. 2, GSP, 01601, Ukraine

SINOPSIS

The neurotropic effect of Psilocybe cubensis (Earle) Sing, dried biomass and fruiting bodies containing the indole hallucinogens psilocybin and psilocine on spike activity of pyramidal neurons from the rat hippocampal CAl region slices has been studied. Extracellularly responses of 50 neurons were recorded, 34 during the application of biomass extract (BME) and 16 during the application of fruiting body extract (FBE). Of the total number of cells studied, the inhibition resulting from BME and FBE application was observed in 73.5% and 81% of cells, respectively. Inhibition parameters during the BME and FBE application were (in seconds) as follows: latency 59 ± 7 and 67 ± 8 and duration 251 ± 26 and 273 ± 37, respectively. Only 5.9% of neurons showed excitation resulting from BME application and no excitative response was observed during FBE application. During the BME and FBE application a short burst occurred in 29% and 12.5% of neurons, respectively. Ritancerin (antagonist of 5-HT2/5-HT1C serotonin receptors) blocked inhibitory responses resulting from BME and FBE application in half of the units tested. The duration of response to serotonin could reach 10−43 min whereas the response to extract application usually did not exceed 4−5 min. Extract application inhibited excitation spike responses resulting from L-glutamic acid application. Results that have been obtained show that the application of psilocybin-containing extracts from mushroom fruiting bodies and biomass causes a similar inhibition pattern of spike activity in pyramidal neurons from the hippocampal CA1 region and inhibits excitation of these neurons caused by L-glutamic acid.


Articles with similar content:

Effects of Amanita Species Extracts on Neuron Responses in the Rat Hippocampal Stratum Pyramidal (CA1 Region) in Vitro
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 4
Solomon P. Wasser, Mykhaylo Moldavan, Victor M. Storozhuk, Anna A. Grodzinskaya
Neurotropic Effect of the Edible and Medicinal Mushroom Lentinus edodes (Berk.) Sing. Extracts on the Neurons of Hippocampal Slices in Rats
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 1
Mykhaylo Moldavan, Victor M. Storozhuk, Anna A. Grodzinskaya
Neurotropic and Trophic Action of Lion's Mane Mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) Extracts on Nerve Cells in Vitro
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 1
Mykhaylo Moldavan, Burkhard Kirchhoff, Paola Pedarzani, Andriy P. Grygansky, Olena V. Kolotushkina, Galina G. Skibo
Activation of Hippocampal Pyramidal Neurons N-Methyl-D-Aspartate Receptors and M-cholinoreceptors During the Application of Amanita (Pers.: Fr.) Hook. Species Extracts
International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 1
Mykhaylo Moldavan, Victor M. Storozhuk, Anna A. Grodzinskaya
Ca2+/Calmodulin Signaling in NMDA-lnduced Synaptic Plasticity
Critical Reviews™ in Neurobiology, Vol.14, 2000, issue 2
Margaret E. Gnegy