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International Journal of Medicinal Mushrooms
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ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i11.80
pages 1037-1047

In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor

Jorge Suarez-Medellin
Centro de Investigaciones Cerebrales (CICE), Universidad Veracruzana. Av. Dr. Luis Castelazo Ayala s/n, Colonia Industrial Animas, 9119, Xalapa, Veracruz, Mexico
Thuluz Meza-Menchaca
Laboratorio de Genómica Humana, Facultad de Medicina, Universidad Veracruzana, Xalapa, México
Joaquin Antonio Quiroz Carranza
Facuitad de Ciencias Naturales, Universidad Autonoma de Queretaro, Queretaro, Mexico
Ángel Trigos
Centro de Investigaciones Biomédicas, Universidad Veracruzana, Luis Castelazo, Animas, Xalapa, Veracruz, México; Laboratorio de Alta Tecnologia de Xalapa, Universidad Veracruzana, Xalapa, Veracruz, México
Abraham M. Vidal-Limon
Departamento de Nanoestructuras, Centro de Nanociencias y Nanotecnologia, Universidad Nacional Autonoma de Mexico, Baja California, México

SINOPSIS

The metabolism of vitamin D is a very important pathway involved in the regulation of sterols and maintenance of cell health. The physiological activity of the human hormone 1α,25-dihydroxyvitamin D3, or calcitriol, is mediated by the vitamin D receptor (VDR), an endocrine member of the nuclear receptor superfamily that inhibits cell growth and stimulates cell differentiation, suggesting a potential application in cancer chemoprevention. Since nonpolar extracts obtained from Ganoderma mushrooms have also been shown to exert an antiproliferative effect on several cancer cell lines, it was suggested that at least part of its activity might be mediated by VDR. The aim of this work was to identify possible VDR ligands from an extensive library of lanostanoids isolated from several Ganoderma mushrooms. Using an in silico approach, 30 lanostanoids were found to interact with the VDR ligand-binding pocket in the same way as calcitriol. The possible implications of using these compounds are discussed here.


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