Publicado 12 números por año
ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344
Indexed in
Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice
SINOPSIS
In this study, we investigated the anti-inflammatory and tumor-inhibiting effects of eburicoic acid, the main bioactive component in the Laetiporus sulphureus, on gastric ulcers. A total of 48 Kunming mice were randomly divided into six groups: control, model, OL (omeprazole, 20 mg/kg/day, orally), EA-L (eburicoic acid, 10 mg/kg/day, orally), EA-M (eburicoic acid, 20 mg/kg/day, orally), and EA-H (eburicoic acid, 40 mg/kg/day, orally). Gastric ulcers were induced in mice by administering 80% ethanol containing 15 mg/mL aspirin (10.0 mL/kg, i.g.) 4 hours after drug administration on day 5. The ulcer index and H+/K+-ATPase activity were evaluated in vivo. Computer-aided molecular docking simulated the interaction between eburicoic acid and H+/K+-ATPase. The results showed that the oral administration of eburicoic acid protected the gastric mucosa from gastric lesions morphologically and especially attenuated H+/K+-ATPase activity. The results of this study indicate that the gastric protective effect of eburicoic acid might inhibit gastric acid.
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Wang Junzhi, Zhang Pan, He Haibo, Se Xinxin, Sun Wenjun, Chen Beiyan, Zhang Lin, Yan Ximing, Zou Kun, Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrill attenuates inflammatory responses through inhibiting LPS-induced activation of PI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells, Naunyn-Schmiedeberg's Archives of Pharmacology, 390, 8, 2017. Crossref
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Yang Yan-Long, Tao Qiao-Qiao, Han Jun-Jie, Bao Li, Liu Hong-Wei, Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China, in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref
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Li Qiang, Yang Mei, Chen Cheng, Xiong Chuan, Jin Xin, Pu Zhigang, Huang Wenli, Characterization and phylogenetic analysis of the complete mitochondrial genome of the medicinal fungus Laetiporus sulphureus, Scientific Reports, 8, 1, 2018. Crossref
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Hamano Hirofumi, Niimura Takahiro, Horinouchi Yuya, Zamami Yoshito, Takechi Kenshi, Goda Mitsuhiro, Imanishi Masaki, Chuma Masayuki, Izawa-Ishizawa Yuki, Miyamoto Licht, Fukushima Keijo, Fujino Hiromichi, Tsuchiya Koichiro, Ishizawa Keisuke, Tamaki Toshiaki, Ikeda Yasumasa, Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway, Toxicology Letters, 318, 2020. Crossref
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Younis Ahmed M., Yosri Mohamed, Stewart Jennifer K., In vitro evaluation of pleiotropic properties of wild mushroom Laetiporus sulphureus, Annals of Agricultural Sciences, 64, 1, 2019. Crossref
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Jiri Patocka, Will the sulphur polypore (laetiporus sulphureus) become a new functional food?, Global Journal of Medical and Clinical Case Reports, 6, 1, 2019. Crossref