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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i1.40
pages 39-43

Polysaccharopeptide from the Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilát Inhibits Human Immunodeficiency Virus Type 1 Reverse Transciptase and Protease

Tzi Bun Ng
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Hexiang Wang
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
D. C. C. Wan
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

SINOPSIS

Polysaccharopeptide from the Turkey Tail fungus Trametes (=Coriolus) versicolor has been reported to possess a number of important attributes including anticancer, immunomodulatory, analgesic, and hepatoprotective activities. In this investigation, it is shown that the polysaccharopeptide is capable of inhibiting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and protease, the two enzymes of paramount importance to the life cycle of the HIV. The polysaccharopeptide inhibits other proteases including trypsin, α-chymotrypsin, proteinase K, subtilisin, and elastase to a smaller extent. The anti-HIV enzyme and immunostimulatory activities of the mushroom polysaccharopeptide make it a potential candidate for the therapy of AIDS.


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