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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Energy and Antioxidant Status of Rat Liver Mitochondria during Hypoxia- Reoxygenation of Different Duration

Volumen 7, Edición 4, 2016, pp. 349-361
DOI: 10.1615/IntJPhysPathophys.v7.i4.70
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SINOPSIS

Changes in the functional activity and protein expression of antiradical Mn-superoxide dismutase (Mn Sod), glutathione-dependent (glutathione peroxidase, glutathione reductase), and NADPH+-generating (isocitrate dehydrogenase) enzymes, as well as the energy metabolism in rat liver mitochondria under hypoxia-reoxygenation of different duration (1, 3, 7, 14 days) were studied. Prolonged hypoxia-reoxygenation was characterized by the phase changes in corticosterone concentration in the rat blood, which corresponded to the changes in energy metabolism and pro and antioxidant balance in rat liver mitochondria. It has been shown that short-term (1day) hypoxia-reoxygenation (5% O2 in the gas mixture) led to an increase in the blood corticosterone concentration and a significant activation of oxidative processes and energy metabolism in rat liver mitochondria, the intensity of which was reduced by the 3rd day. Long-term hypoxia-reoxygenation (7 - 14 days) resulted in gradual depletion of the body adaptive capabilities, as evidenced by a significant decline in blood corticosterone concentration, elevated content of secondary products of lipid peroxidation, imbalance between pro-oxidant and antioxidant reactions, and a reduction of the liver mitochondrial energy capacity. It has been shown that glutathione peroxidase protein expression and enzymatic activity were elevated during the whole experimental period and correlated positively with the level of H2O2. The amount of Mn-SOD protein and enzymatic activity of the latter were lower within first seven days of the experiment and increased in consequent days up to the control level on 14th day. Increased activities of glutathione peroxidase, glutathione reductase, and NADPH+-dependent isocitrate dehydrogenase during prolonged hypoxia-reoxygenation indicate that glutathione and NADPH-generating enzymes are actively involved in the antioxidant protection.

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