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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Mechanism of Apoptosis in Thyroid Cells under Thyroid Pathology

Volumen 1, Edición 2, 2010, pp. 125-139
DOI: 10.1615/IntJPhysPathophys.v1.i2.50
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SINOPSIS

The literature data and the results of own examinations concerning the changes in programming cell death processes of goiter alterated thyroid tissue in patients with euthyroid or toxic goiter and also the extranodular tissue of the gland in the presence of pathological changes in it (the pronounced hyperplastic process, the sclerotic and/or dystrophic changes, the lymphoid infiltration, chronic or autoimmune thyroiditis) were analyzed. It has been cleared that the significant changes in the processes of mitochondria and postmitochondria regulation and apoptosis realization are occurred under thyroid pathology. The character and the degree of disorders in the apoptosis mitochondria mechanisms and the activity of destructive processes in the patient thyroid cells are dependent on many factors such as the pathology type, the severity of its occurrence, the peculiarities of tissue follicular structure and the patient sex. Obtained resistance of the apoptosis mitochondria mechanisms can play an important role in the pathogenesis of thyroid nodular pathology or in the development of inflammatory and autoimmune processes.

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