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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Normobaric Hyperoxia Affects Osteogenesis in Rats

Volumen 4, Edición 1, 2013, pp. 1-9
DOI: 10.1615/IntJPhysPathophys.v4.i1.10
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SINOPSIS

We studied the effects of normobaric hyperoxia on bone metabolism in 3- and 12-month-old male Wistar rats. An exposure of the young rats (3 months) to the 14-hour daily sessions of normobaric hyperoxia (90% O2) is accompanied by a significant decrease in the concentration of C-terminal propeptides of the collagen type I and acid phosphatase activity by 36% and 32%, correspondingly, whereas an activity of alkaline phosphatase increases by 64%, and concentration of pyridinoline, β-CrossLaps and glycosaminoglycans by 37%, 8%, and 72%, respectively, in the blood serum. We believe that 14-day long normobaric hyperoxia (90%) impairs collagen synthesis. In adult rats under the same conditions, the concentration of glycosaminoglycans significantly increases (by 60%) relative to the control values. After 28 sessions of breathing with normobaric gas mixture containing 90% O2, this parameter increases by 195%. Acid phosphatase activity and the tartrat-resistant acid phosphatase activity decrease by 18 − 25% after breathing with normobaric gas mixture containing 40% and 90% O2 for 14 and 28 days. We suggest that in adult animals, 90% hyperoxia does not affect the activity of osteoblasts, but it breaks the link between glycosaminoglycans and collagen fibrils, decreases lysosomal enzyme activities, produced by osteoclasts, which can inhibit osteogenesis.

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