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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Tissue Blood Flow in the Digestive Organs of Rats with Acute Pancreatitis after Corvitin Administration

Volumen 8, Edición 1, 2017, pp. 25-32
DOI: 10.1615/IntJPhysPathophys.v8.i1.30
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SINOPSIS

We have investigated the action of quercetin (in a modified form of Corvitin, Ukraine) on the volumetric blood flow (VBF) in the rat pancreas, the liver and gastric mucosa in L-arginine-induced acute pancreatitis (AP). The VBF was measured by hydrogen clearance method with its electrochemical generation using Polarographs Lr-9 (Czech Republic). During the first 10 days after AP modelling, we observed a gradual decrease in the VBF by 42%, 61%, and 64% (P < 0.01) in the pancreas, the liver, and the gastric mucosa, respectively, compared to the intact animals in the rate of blood flow, that is, the most significant changes occurred in the gastric mucosa and the least pronounced − in the pancreas. Corvitin (5 mg/kg, once per day, from the 11th to the 20th days of experiment) to any extent promoted the recovery of the VBF in all investigated organs: fully in the pancreas, almost completely in the liver, and only partially in the gastric mucosa, compared with the control group of animals with modelling acute pancreatitis and administerating of only saline for 20 days. Thus, based on the obtained results, Corvitin may be recommended as a remedy for partial or complete correction of the blood flow disturbances, arising in the pancreas and other organs of the digestive system in AP, by improving the functional state of these organs in the early stages of the disease and accelerating the full restoration of their functions.

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