Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
SINOPSIS
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
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Burg Jonathan M., Link Jennifer E., Morgan Brittany S., Heller Frederick J., Hargrove Amanda E., McCafferty Dewey G., KDM1 class flavin-dependent protein lysine demethylases, Biopolymers, 104, 4, 2015. Crossref
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Liu Yun-Duo, Dai Meng, Yang Shan-Shan, Xiao Min, Meng Fan-Ling, Chen Xiu-Wei, Overexpression of Lysine-Specific Demethylase 1 Is Associated With Tumor Progression and Unfavorable Prognosis in Chinese Patients With Endometrioid Endometrial Adenocarcinoma, International Journal of Gynecological Cancer, 25, 8, 2015. Crossref
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Sainathan Satheesh, Paul Santanu, Ramalingam Satish, Baranda Joaquina, Anant Shrikant, Dhar Animesh, Histone Demethylases in Cancer, Current Pharmacology Reports, 1, 4, 2015. Crossref
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Lewandowska Hanna, Kalinowska Monika, Lewandowski Włodzimierz, Stępkowski Tomasz M., Brzóska Kamil, The role of natural polyphenols in cell signaling and cytoprotection against cancer development, The Journal of Nutritional Biochemistry, 32, 2016. Crossref
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Patrick Nina M., Griggs Chanel A., Icenogle Ali L., Gilpatrick Maryam M., Kadiyala Vineela, Jaime-Frias Rosa, Smith Catharine L., Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1, The Journal of Steroid Biochemistry and Molecular Biology, 167, 2017. Crossref
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Bennesch Marcela A., Segala Gregory, Wider Diana, Picard Didier, LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP, Nucleic Acids Research, 44, 18, 2016. Crossref
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Han Chao, Li Zhongrui, Hou Jiqin, Wang Zhen, Xu Dingqiao, Xue Guimin, Kong Lingyi, Bioactivity evaluation of natural product α-mangostin as a novel xanthone-based lysine-specific demethylase 1 inhibitor to against tumor metastasis, Bioorganic Chemistry, 76, 2018. Crossref
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Lan Huiyin, Tan Mingjia, Zhang Qiang, Yang Fei, Li Hua, Xiong Xiufang, Sun Yi, LSD1 Destabilizes FBXW7 Independent of Its Demethylase Activity, SSRN Electronic Journal , 2018. Crossref
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Clark Erin A., Wu Feizhen, Chen Yirui, Kang Paco, Kaiser Ursula B., Fang Rui, Shi Yujiang G., GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers, Cell Reports, 27, 12, 2019. Crossref
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He Xingrui, Gao Yuan, Hui Zi, Shen Guodong, Wang Shuo, Xie Tian, Ye Xiang-Yang, 4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors, Bioorganic & Medicinal Chemistry Letters, 30, 10, 2020. Crossref
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Özenver Nadire, Efferth Thomas, Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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Noh Seong Woo, Seo Ri-Ra, Park Hee Jin, Jung Ho Won, Two Arabidopsis Homologs of Human Lysine-Specific Demethylase Function in Epigenetic Regulation of Plant Defense Responses, Frontiers in Plant Science, 12, 2021. Crossref
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Rivière Céline, Hennebelle Thierry, Plant Kingdom as Source of Vitamins, in Handbook of Dietary Phytochemicals, 2021. Crossref
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Al-Eidan Ahood, Wang Yihua, Skipp Paul, Ewing Rob M., The USP7 protein interaction network and its roles in tumorigenesis, Genes & Diseases, 9, 1, 2022. Crossref
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Rauscher Stefanie, Greil Richard, Geisberger Roland, Re-Sensitizing Tumor Cells to Cancer Drugs with Epigenetic Regulators, Current Cancer Drug Targets, 21, 4, 2021. Crossref
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Xi Jiayue, Xu Siyuan, Wu Liming, Ma Tianfang, Liu Rongfeng, Liu Yu-Chih, Deng Dawei, Gu Yueqing, Zhou Jinpei, Lan Fei, Zha Xiaoming, Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors, Bioorganic Chemistry, 72, 2017. Crossref
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Wang Shuai, Zhao Li-Jie, Zheng Yi-Chao, Shen Dan-Dan, Miao Er-Fei, Qiao Xue-Peng, Zhao Li-Juan, Liu Ying, Huang Ruilei, Yu Bin, Liu Hong-Min, Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors, European Journal of Medicinal Chemistry, 125, 2017. Crossref
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Ge Wenshu, Liu Yunsong, Chen Tong, Zhang Xiao, Lv Longwei, Jin Chanyuan, Jiang Yong, Shi Lei, Zhou Yongsheng, The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1, Biomaterials, 35, 23, 2014. Crossref
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Nicosia Luciano, Boffo Francesca Ludovica, Ceccacci Elena, Conforti Fabio, Pallavicini Isabella, Bedin Fabio, Ravasio Roberto, Massignani Enrico, Somervaille Tim C. P., Minucci Saverio, Bonaldi Tiziana, Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML, Oncogene, 41, 6, 2022. Crossref
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Wang Jiming, Zhang Xiangyu, Yan Jiangkun, Li Wei, Jiang Qinwen, Wang Xinran, Zhao Dongmei, Cheng Maosheng, Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors, Bioorganic & Medicinal Chemistry Letters, 29, 23, 2019. Crossref
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Moreno Jose Duran, Papageorgiou Georgios, Gazouli Ioanna, Kyriazoglou Anastasios, Systemic Treatment of Ewing Sarcoma: Current Options and Future Perspectives, Forum of Clinical Oncology, 2022. Crossref
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Oršolić Nada, Jazvinšćak Jembrek Maja, Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer, International Journal of Molecular Sciences, 23, 18, 2022. Crossref