Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 2.156 Factor de Impacto de 5 años: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Volumes:
Volumen 30, 2020 Volumen 29, 2019 Volumen 28, 2018 Volumen 27, 2017 Volumen 26, 2016 Volumen 25, 2015 Volumen 24, 2014 Volumen 23, 2013 Volumen 22, 2012 Volumen 21, 2011 Volumen 20, 2010 Volumen 19, 2009 Volumen 18, 2008 Volumen 17, 2007 Volumen 16, 2006 Volumen 15, 2005 Volumen 14, 2004 Volumen 13, 2003 Volumen 12, 2002 Volumen 11, 2001 Volumen 10, 2000 Volumen 9, 1999 Volumen 8, 1998 Volumen 7, 1997 Volumen 6, 1996 Volumen 5, 1995 Volumen 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.2013006641
pages 93-101

ANP-NPRA Signaling Pathway−A Potential Therapeutic Target for the Treatment of Malignancy

Zhilong Zhao
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jia Zhang
Department of Thoracic Surgery, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Min Li
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ya Yang
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Kai Sun
Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China
Jiansheng Wang
Tianjin University

SINOPSIS

It was well established that the atrial natriuretic peptide (ANP)/natriuretic peptide receptor-A (NPRA) signaling pathway controls natriuretic, diuretic, vasorelaxant, and anti-proliferative responses in the regulation of the human cardiovascular system by previous studies. Yet in recent years, more and more evidence has shown that the ANP/NPRA signaling pathway plays an important role in human cancer. For example, NPRA is abundantly expressed on tumorigenic mouse and human prostate cancer (PCa) cells, but not in nontumorigenic prostate epithelial cells and down-regulation of NPRA-induced apoptosis in PCa cells. Dexamethasone can increase the expression of ANP markedly, and that is the reason why dexamethasone is the cornerstone in the treatment of multiple myeloma. NPRA deficiency can substantially protect C57BL/6 mice from lung, skin, and ovarian cancers. These results strongly suggest ANP and NPRA may play an anti-cancer and carcinogenesis role, respectively, and this signaling pathway could be a more potent target for cancer therapy. In light of these new insights, this review will summarize the structures, functions, and their regulation by cell signaling, and their different impacts on tumors.

PALABRAS CLAVE: ANP, NPRA, cancer, target, treatment

Articles with similar content:

The c-Fes Family of Protein-Tyrosine Kinases
Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Jim A. Rogers, Annemarie Shibata, Haiyun Cheng, Thomas E. Smithgall, Steven Schreiner, Kristi L. Peters, Jack M. Lionberger, Nancy Dunham, Jianze Li, Scott D. Briggs, Beata Scholtz
Enzymatic and Extraenzymatic Role of Adenosine Deaminase 1 in T-Cell-Dendritic Cell Contacts and in Alterations of the Immune Function
Critical Reviews™ in Immunology, Vol.27, 2007, issue 6
Rodrigo Pacheco, Rafael Franco, Carme Lluis, Teresa Gallart, Josep Maria Gatell
p120-CATENIN: A NOVEL REGULATOR OF INNATE IMMUNITY AND INFLAMMATION
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Guochang Hu
Immunomodulatory and Cytoprotective Function of Atrial Natriuretic Peptide
Critical Reviews™ in Immunology, Vol.21, 2001, issue 6
Alexandra K. Kiemer, Angelika M. Vollmar
Hypotensive Activity of Mushroom Lectin of Tricholoma mongolicum S. Imai (Agaricomycetideae) in Comparison with Some Plant Lectins
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 4
Vincent Eng Choo Ooi, Hexiang Wang, Tzi Bun Ng