Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013893
pages 209-238

Genes Associated with Human Cancers: Their Expressions, Features, Functions, and Significance

Ravi Maddaly
Department of Human Genetics, Faculty of Biomedical Sciences, Technology, and Research, Sri Ramachandra University, Porur, Chennai 600116, India
Bellona Sahu
Department of Human Genetics, Faculty of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, India
Divya K. Mohan
Department of Human Genetics, Faculty of Biomedical Sciences, Sri Ramachandra University, Porur, Chennai, India

SINOPSIS

Various types of cancer continue to be subjects of intense research because of the impact of these diseases and their socioeconomic implications. Also, the complexity involved in the pathogenesis, nature of the triggers, and the progression of cancers is intriguing. An important aspect of cancers is the genetics involved, and studies involving cancer genes contributed immensely in not only understanding cancers better, but also for obtaining useful markers and therapy targets. We review the salient features, functions, and changes in gene expression for 103 carcinoma genes, 20 sarcoma genes, and 36 lymphoma genes. Apart from the three major levels of cancer type, we discuss the implications of altered gene expression at the tissue level as well. The possible uses of these gene functions and expression changes for diagnostic, prognostic, and therapeutic applications are presented. Also, the 159 genes are assessed for their involvement in more than a single cancer and tissue type. Only the p53 gene is commonly implicated in carcinomas, sarcoma and lymphomas. The CHEK2 and ERBB2 (HER2) genes are commonly found to be associated with carcinomas and sarcomas, whereas the MDM2, MSH2, and MSH6 genes are commonly implicated among carcinomas and lymphomas.


Articles with similar content:

Recent Developments in the Molecular Genetic Understanding of Breast Cancer
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
E. Schuuring, M. J. van de Vijver, C. J. Cornelisse, P. Devilee
Colorectal Cancer: A Multipathway Disease
Critical Reviews™ in Oncogenesis, Vol.12, 2006, issue 3-4
Jeremy R. Jass
Genomic Pathology and Biomarkers in Breast Cancer
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Ping Tang, Zhang Zhang
Immunopathogenesis of the Anti-Synthetase Syndrome
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Yurdagül Uzunhan, Baptiste Hervier, Vincent Vieillard, Catherine Gayed, Isabelle Cremer
Emerging Roles of MicroRNAs in the Wnt Signaling Network
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Troels Schepeler