Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 2.156 Factor de Impacto de 5 años: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Volumes:
Volumen 30, 2020 Volumen 29, 2019 Volumen 28, 2018 Volumen 27, 2017 Volumen 26, 2016 Volumen 25, 2015 Volumen 24, 2014 Volumen 23, 2013 Volumen 22, 2012 Volumen 21, 2011 Volumen 20, 2010 Volumen 19, 2009 Volumen 18, 2008 Volumen 17, 2007 Volumen 16, 2006 Volumen 15, 2005 Volumen 14, 2004 Volumen 13, 2003 Volumen 12, 2002 Volumen 11, 2001 Volumen 10, 2000 Volumen 9, 1999 Volumen 8, 1998 Volumen 7, 1997 Volumen 6, 1996 Volumen 5, 1995 Volumen 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.60
pages 363-377

Mesenchymal Stem Cells in the Aging and Osteoporotic Population

Francesca Veronesi
University of Bologna
Paola Torricelli
Preclinical and Surgical Studies Laboratory, Codivilla-Putti Research Institute - Rizzoli Orthopedic Institute, Bologna-Italy; Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic
Veronica Borsari
Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic Institute, Bologna-Italy
Matilde Tschon
Preclinical and Surgical Studies Laboratory, Codivilla-Putti Research Institute - Rizzoli Orthopedic Institute, Bologna-Italy; Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic
Lia Rimondini
Laboratory of Biomedical and Dental Materials, Department of Health Sciences, Universita del Piemonte Orientale "A. Avogadro", (NO), Italy; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), (FI), Italy
Milena Fini
Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy

SINOPSIS

Because of their ability to self-renew and differentiate, mesenchymal stem cells (MSCs) are the in vivo source for replacing lost cells in high-turnover tissues during the life of an organism. MSCs have osteogenic potential and can be eligible for the repair and maintenance of the skeleton, thus they are very attractive for tissue engineering and regenerative medicine approaches. However, many changes in their behavior, caused by aging and bone disease, have been reported in the literature. These changes, which affect MSC self-renewal ability and differentiation potentiality, are related to cell proliferation, differentiation, cell cycle phases (depending on gene modification), and cytokine and growth factor production. This review summarizes the literature related to intrinsic and extrinsic characteristics of human bone marrow or adipose tissue MSCs during aging and osteoporosis. Although some studies reveal contrasting results, the results of this review suggest that the cellular modifications due to aging and osteoporosis should be carefully considered in relation to the use of MSCs for therapeutic application.


Articles with similar content:

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 2
Cheryl Ackert-Bicknell, Juan Pablo Rodriguez, Ana Maria Pino, Clifford J. Rosen
Bone Tissue Engineering: Recent Advances and Challenges
Critical Reviews™ in Biomedical Engineering, Vol.40, 2012, issue 5
Syam P. Nukavarapu, Cato T. Laurencin, Ami R. Amini
Programming hMSCs into Potential Genetic Therapy in Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 4
Nedime Serakinci, Huseyin Cagsin
Osteopoiesis: The Early Development of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 3&4
Michael W. Long, Sujata Kale
Human Umbilical Cord–Derived Stem Cells: Isolation, Characterization, Differentiation, and Application in Treating Diabetes
Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Bhawna Chandravanshi, Ramesh R. Bhonde