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Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Functional Implications of BRCA1 for Early Detection, Prevention, and Treatment of Breast Cancer

Volumen 16, Edición 3, 2006, pp. 233-252
DOI: 10.1615/CritRevEukarGeneExpr.v16.i3.30
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SINOPSIS

The tumor suppressor gene BRCA1 was positionally cloned in 1994. During the last 12 years, several lines of evidence have implicated BRCA1 in the maintenance of genome integrity, regulation of transcriptionn, and chromatin remodeling, suggesting that it has multiple biological roles. Germline mutations in BRCA1 confer a 56%−80% lifetime risk for breast cancer and a 15%−60% lifetime risk for ovarian cancer in women. And preliminary evidence suggests that BRCA1-linked breast and ovarian tumors behave differently from sporadic tumors, justifying a tailored approach to these cancers. Although several gaps still remain in our knowledge, it is possible to use information from basic research to illuminate clinical decisions and improve the prospects of mutation carriers. Along similar lines, genetic data derived from the clinical setting are also instrumental in determining which biochemical functions of BRCA1 contribute to its tumor suppressor actions. In this article, we explore the functional implications of BRCA1 for genetic testing (early detection), prevention, and therapy.

CITADO POR
  1. Millot Gaël A., Carvalho Marcelo A., Caputo Sandrine M., Vreeswijk Maaike P.G., Brown Melissa A., Webb Michelle, Rouleau Etienne, Neuhausen Susan L., Hansen Thomas v. O., Galli Alvaro, Brandão Rita D., Blok Marinus J., Velkova Aneliya, Couch Fergus J., Monteiro Alvaro N.A., A guide for functional analysis ofBRCA1variants of uncertain significance, Human Mutation, 33, 11, 2012. Crossref

  2. Ren Jie, Jin Feng, Yu Zhaojin, Zhao Lin, Wang Lin, Bai Xuefeng, Zhao Haishan, Yao Weifan, Mi Xiaoyi, Wang Enhua, Olopade Olufunmilayo I., Wei Minjie, MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency, Tumor Biology, 34, 6, 2013. Crossref

  3. Carvalho Renato S, Fernandes Vanessa C, Nepomuceno Thales C, Rodrigues Deivid C, Woods Nicholas T, Suarez-Kurtz Guilherme, Chammas Roger, Monteiro Alvaro N, Carvalho Marcelo A, Characterization ofLGALS3(galectin-3) as a player in DNA damage response, Cancer Biology & Therapy, 15, 7, 2014. Crossref

  4. Price Melissa, Monteiro Alvaro N.A., Fine tuning chemotherapy to match BRCA1 status, Biochemical Pharmacology, 80, 5, 2010. Crossref

  5. Lai Dulcie, Visser-Grieve Stacy, Yang Xiaolong, Tumour suppressor genes in chemotherapeutic drug response, Bioscience Reports, 32, 4, 2012. Crossref

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