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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.2013006666
pages 49-64

Brucella Virulence Mechanisms and Implications in Novel Vaccines and Drugs

Guangjun Gao
College of Pharmaceutical Science, Southwest University, Chongqing, 400716, China; Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, 100071, China
Yufei Wang
Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, 100071, China
Zeliang Chen
Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, 100071, China
Xingran Xu
College of Pharmaceutical Science, Southwest University, Chongqing, 400716, China
Jie Xu
School of Public Health, Research Center for Genomic Medicine, Jilin University; Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, 100071, China

SINOPSIS

Brucellosis, an infection caused by Brucella spp., is a common zoonosis in many parts of world. Human chronic infection is successfully established through contact with infected animals or their dirty products. The capacity of establishing and maintaining this persistent infection in the phagosomal compartment of host macro-phages is critical to their ability to produce chronic infections in their mammalian hosts. Bacterial virulence mechanisms play an important role in regulating during the infectious process, both to optimize the functioning of the virulence factors in promoting survival and thwarting host defenses and to produce an effective immune response against these virulence components. The availability of the genomic sequences and molecular strategies such as gene mutant technique provide an opportunity to identify the virulence mechanisms of Brucella. It will greatly accelerate our understanding of the infection of this pathogen and give us more clues to exploit new vaccines and drugs.


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