Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Two-Stage Gene Regulation of the Superoxide Stress Response soxRS System in Escherichia Coli
SINOPSIS
All organisms have adapted to environmental changes by acquiring various functions controlled by gene regulation. In bacteria, a number of specific responses have been found to confer cell survival in various nutrient-limited conditions, and under physiological stresses such as high or low temperature, extreme pH, radiation, and oxidation (for review, see Neidhardt et al., 1987). In this article, I introduce an Escherichia coli (E. coli) global response induced by superoxide stress, the soxRS regulon. The functions controlled by this system consist of a wide variety of enzymes such as manganese-containing SOD (Mn-SOD), glucose 6-phosphate dehydrogenase (G6PD), the DNA repair enzyme endonuclease IV, fumarase C, NADPH:ferredoxin oxidoreductase, and aconitase. This response is positively regulated by a two-stage control system in which SoxR iron-sulfur protein senses exposure to superoxide and nitric oxide, and then activates transcription of the soxS gene, whose product stimulates the expression of the regulon genes. Our recent finding indicates that soxS transcription is initiated in a manner dependent on the rpoS gene encoding RNA polymerase sigma factor,σs, in response to entering the stationary phase of growth. With this information, mechanisms for prokaryotic coordinating gene expression in response to superoxide stress and in stationary phase are discussed.
-
Armstrong Jeffrey S., Whiteman Matthew, Yang Hongyuan, Jones Dean P., The redox regulation of intermediary metabolism by a superoxide-aconitase rheostat, BioEssays, 26, 8, 2004. Crossref
-
Zeller Tanja, Klug Gabriele, Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes, Naturwissenschaften, 93, 6, 2006. Crossref
-
Thongphasuk Jarunee, Oberley Larry W., Oberley Terry D., Induction of Superoxide Dismutase and Cytotoxicity by Manganese In Human Breast Cancer Cells, Archives of Biochemistry and Biophysics, 365, 2, 1999. Crossref
-
Benov Ludmil, Batinić-Haberle Ines, Spasojević Ivan, Fridovich Irwin, Isomeric N-alkylpyridylporphyrins and their Zn(II) complexes: inactive as SOD mimics but powerful photosensitizers, Archives of Biochemistry and Biophysics, 402, 2, 2002. Crossref
-
Tindale Anne E., Mehrotra Manisha, Ottem Derek, Page William J., Dual regulation of catecholate siderophore biosynthesis in Azotobacter vinelandii by iron and oxidative stress The GenBank accession number for the sequence reported in this paper is AF238500., Microbiology, 146, 7, 2000. Crossref
-
Voskuil Martin I. , Schnappinger Dirk , Visconti Kevin C. , Harrell Maria I. , Dolganov Gregory M. , Sherman David R. , Schoolnik Gary K. , Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program , Journal of Experimental Medicine, 198, 5, 2003. Crossref
-
Garnica Omar A., Das Kishore, Dhandayuthapani Subramanian, OhrR of Mycobacterium smegmatis senses and responds to intracellular organic hydroperoxide stress, Scientific Reports, 7, 1, 2017. Crossref
-
Si Meiru, Su Tao, Chen Can, Liu Jinfeng, Gong Zhijin, Che Chengchuan, Li GuiZhi, Yang Ge, OhsR acts as an organic peroxide-sensing transcriptional activator using an S-mycothiolation mechanism in Corynebacterium glutamicum, Microbial Cell Factories, 17, 1, 2018. Crossref
-
Zhang Pengfei, Ye Zhicang, Ye Chen, Zou Haijie, Gao Zhichao, Pan Jianyi, OmpW is positively regulated by iron via Fur, and negatively regulated by SoxS contribution to oxidative stress resistance in Escherichia coli, Microbial Pathogenesis, 138, 2020. Crossref
-
Saikolappan Sankaralingam, Sasindran Smitha J., Yu Hongwei D., Baseman Joel B., Dhandayuthapani Subramanian, The Mycoplasma genitalium MG_454 Gene Product Resists Killing by Organic Hydroperoxides , Journal of Bacteriology, 191, 21, 2009. Crossref
-
de Vries Nicolette, van Vliet Arnoud H.M., Kusters Johannes G., Gene Regulation, in Helicobacter pylori, 2014. Crossref
-
Nunoshiba Tatsuo, Yamamoto Kazuo, Role of glutathione on acrolein-induced cytotoxicity and mutagenicity in Escherichia coli, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 442, 1, 1999. Crossref
-
Kaidow Akihiro, Ishii Noriko, Suzuki Shingo, Shiina Takashi, Kasahara Hirokazu, Vitamin C Maintenance against Cell Growth Arrest and Reactive Oxygen Species Accumulation in the Presence of Redox Molecular Chaperone hslO Gene, International Journal of Molecular Sciences, 23, 21, 2022. Crossref