Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 2.156 Factor de Impacto de 5 años: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Volumes:
Volumen 30, 2020 Volumen 29, 2019 Volumen 28, 2018 Volumen 27, 2017 Volumen 26, 2016 Volumen 25, 2015 Volumen 24, 2014 Volumen 23, 2013 Volumen 22, 2012 Volumen 21, 2011 Volumen 20, 2010 Volumen 19, 2009 Volumen 18, 2008 Volumen 17, 2007 Volumen 16, 2006 Volumen 15, 2005 Volumen 14, 2004 Volumen 13, 2003 Volumen 12, 2002 Volumen 11, 2001 Volumen 10, 2000 Volumen 9, 1999 Volumen 8, 1998 Volumen 7, 1997 Volumen 6, 1996 Volumen 5, 1995 Volumen 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v18.i4.10
pages 279-321

Expression and Activity of Aryl Hydrocarbon Receptors in Development and Cancer

Thomas A. Gasiewicz
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY
Ellen C. Henry
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY
Loretta L. Collins
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY

SINOPSIS

Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity of particular xenobiotics such as the dioxins, the normal role of this transcription factor in a number of biological processes is just beginning to be recognized. Knowledge of AhR-targeted genes and signaling pathways indicates involvement of AhR in fundamental cell-regulatory pathways. Noted defects in the morphology and functions of certain tissues in the absence of AhR point to critical roles for this protein in developmental processes. Together, the data suggest that the AhR has an important function in controlling the balance among processes involved in cell proliferation, death, and differentiation rather than being essential for them. On the other hand, deregulation of these processes is known to contribute to events such as tumor initiation, promotion, and progression that ultimately lead to malignant tumor formation. Epidemiological and experimental animal data, along with a more detailed understanding of how AhR is involved in regulating particular signaling pathways, provide substantial support for an association between abnormal AhR function and cancer. Here we describe the current understanding of how the AhR may function to regulate both normal and cancerous tissue growth and development.


Articles with similar content:

The Epigenetics of Adult (Somatic) Stem Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 3
Kenneth J. Eilertsen, Z. Elizabeth Floyd, Jeffrey M. Gimble
Therapeutic Intervention with Breast Cancer Metastasis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 2
Dina Chelouche Lev, Janet E. Price
Targeting the Regulatory Machinery of BIM for Cancer Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Steven Grant, Hisashi Harada
Tracking Down the Origin of Cancer: Metabolic Reprogramming as a Driver of Stemness and Tumorigenesis
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 5
Carlos Sebastian
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 3
J. Luis Morales, Brett D. Hollingshead, Gary H. Perdew, Timothy V. Beischlag