Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 2.156 Factor de Impacto de 5 años: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Volumes:
Volumen 30, 2020 Volumen 29, 2019 Volumen 28, 2018 Volumen 27, 2017 Volumen 26, 2016 Volumen 25, 2015 Volumen 24, 2014 Volumen 23, 2013 Volumen 22, 2012 Volumen 21, 2011 Volumen 20, 2010 Volumen 19, 2009 Volumen 18, 2008 Volumen 17, 2007 Volumen 16, 2006 Volumen 15, 2005 Volumen 14, 2004 Volumen 13, 2003 Volumen 12, 2002 Volumen 11, 2001 Volumen 10, 2000 Volumen 9, 1999 Volumen 8, 1998 Volumen 7, 1997 Volumen 6, 1996 Volumen 5, 1995 Volumen 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i2.20
18 pages

Complex Smad-Dependent Transcriptional Responses in Vertebrate Development and Human Disease

Leo A. van Grunsven
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium
Danny Huylebroeck
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium
Kristin Verschueren
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium

SINOPSIS

Smad proteins mediate genomic responses to polypeptides of the transforming growth factor type b (TGF-b) family, affecting cellular proliferation and differentiation, adhesion, and death. Members of one class of these Smad proteins, the receptor-regulated Smads or R-Smads, accumulate in the nucleus on their activation byligand-bound complexes of serine-threonine kinase receptors at the cell surface. These effector proteins then participate directly in the regulation of gene expression by binding to DNA, interacting with transcription factors, and recruiting corepressors or coactivators to specific promoters. Although many nuclear Smad-interacting factors were isolated during the last 3 years, the field has recently taken a step beyond the characterization of the activity of these Smad-containing complexes on gene expression in vitro, as it addresses now their contribution to many processes in vivo. We have selected examples of such recent progress to illustrate the remarkable variation in the molecular mechanisms underlying Smad-dependent signaling depending on the non-Smad partner in the nucleus and their relevance to normal embryogenesis and consequences of their deregulation in human disorders and pathology.


Articles with similar content:

Regulation of the Function of Eosinophils and Basophils
Critical Reviews™ in Immunology, Vol.17, 1997, issue 3-4
Toshiaki Takaishi, Koichi Hirai, Yutaka Morita, Misato Miyamasu
Emerging Roles of MicroRNAs in the Wnt Signaling Network
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Troels Schepeler
CD14+ Monocytes as Dendritic Cell Precursors: Diverse Maturation-Inducing Pathways Lead to Common Activation of NF-kB/RelB
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Peter A. Cohen, Gary K. Koski, Lyudmila A. Lyakh, Nancy R. Rice
Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Aswathy K. Nair, Eric D. Jensen, Jennifer J. Westendorf
Regulation of Osteoblast Growth by Interactions Between Transforming Growth Factor-b and 1a,25-Dihydroxyvitamin D3
Critical Reviews™ in Eukaryotic Gene Expression, Vol.11, 2001, issue 4
Rajiv Kumar, Alper Gurlek