Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2018027399
pages 37-45

Mini-Review: The Non-Immune Functions of Toll-Like Receptors

Ying Song
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China
Li Meng Shou
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China; The Second Affiliated Hospital, Zhejiang University School of Medicine (SAHZU) SAHZU International Medical Center, No. 590, North Shixin Road, XiaoShao District, Hangzhou City, Zhejiang Province 310009, P.R. China
Li-Yao Ai
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China
Yun Bei
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China
Man-Ting Chen
Department of Pharmacology, Zhejiang University of Technology, 18# Chaowang Road, Hangzhou City, Zhejiang Province 310014, P.R. China

SINOPSIS

Toll-like receptors (TLRs) are a family of highly conserved pattern recognition receptors that can recognize both pathogen-associated molecular patterns and danger-associated molecular patterns. These receptors are important in the activation of the innate immune system and play a role in shaping the adaptive immune system. For years, the expression of TLRs in the brain has been proposed to contribute to the immunological protection of the central nervous system. However, emerging studies have provided increasing evidence of non-immune functions of TLRs and suggest that these receptors may participate in more complex processes that extend beyond the regulation of the innate immune response. In this review, we highlight the expression of TLRs in non-immune cells and epitomize TLR non-immune functions. We aim to reveal the novel roles of TLRs that are distinct from their traditional functions in immunity. Negative regulatory approaches used to study TLR signaling pathways are also discussed, providing potential directions for further studies.


Articles with similar content:

The Role of Toll-like Receptors in Regulating the Immune Response against Respiratory Syncytial Virus
Critical Reviews™ in Immunology, Vol.29, 2009, issue 6
Frank Coenjaerts, Grada M. van Bleek, Lydia Tan, Peter Klein Klouwenberg, Wendy Werkman
Role of Dendritic Cells in Host−Mycobacterium Bovis BCG Interactions
Forum on Immunopathological Diseases and Therapeutics, Vol.6, 2015, issue 3-4
Krzysztof Krawczyk, Magdalena Kowalewicz-Kulbat, Wieslawa Rudnicka
CD5 as a Target for Immune-Based Therapies
Critical Reviews™ in Immunology, Vol.35, 2015, issue 2
Fernando Aranda, Marc Orta, Ines Simoes, Marta Consuegra-Fernandez, Francisco Lozano, Adelaida Sarukhan
Signal Integration Following Toll-like Receptor Triggering
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Alexander Dalpke, Klaus Heeg
Transcription Factors and Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Guobing Chen, M. Frances Shannon