Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Nuclear Matrix Targeting of Steroid Receptors: Specific Signal Sequences and Acceptor Proteins
SINOPSIS
The nuclear matrix provides the framework for various processes that occur within the nucleus such as transcription, replication, and splicing. As the composition of the nuclear matrix varies between different cell types, the matrix may influence cell-type-specific gene expression. A number of transcription factors have been shown to be associated with the nuclear matrix, including steroid hormone receptors that were the first transcriptional regulatory proteins localized to this compartment. In this review we highlight the most recent advances in our understanding of steroid hormone receptor targeting to the matrix. A specific nuclear matrix targeting signal (NMTS) has been identified within the glucocorticoid receptor (GR) that includes portions of its DNA-binding domain and tau2 transactivation domains. Distinct nuclear matrix acceptor proteins appear to interact within the GR NMTS and impart divergent effects on the transcriptional regulatory properties of the receptor.
-
Li Xiangen, Vradii Diana, Gutierrez Soraya, Lian Jane B., van Wijnen Andre J., Stein Janet L., Stein Gary S., Javed Amjad, Subnuclear targeting of Runx1 Is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1, Journal of Cellular Biochemistry, 96, 4, 2005. Crossref
-
Hashimoto Takashi, Matsuda Ken-Ichi, Kawata Mitsuhiro, Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα, Journal of Cellular Biochemistry, 113, 9, 2012. Crossref
-
Zaidi Sayyed K., Young Daniel W., Javed Amjad, Pratap Jitesh, Montecino Martin, van Wijnen Andre, Lian Jane B., Stein Janet L., Stein Gary S., Nuclear microenvironments in biological control and cancer, Nature Reviews Cancer, 7, 6, 2007. Crossref
-
Vidaković Melita, Dinić Svetlana, Grdović Nevena, Mihailović Mirjana, Uskoković Aleksandra, Quesada Piera, Poznanović Goran, Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix, Journal of Cellular Biochemistry, 107, 6, 2009. Crossref
-
Li Hui Joyce, Haque Zaffar K., Chen Amy, Mendelsohn Michael, RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix, Journal of Cellular Biochemistry, 102, 4, 2007. Crossref
-
Djabali Karima, Christiano Angela M., Hairless contains a novel nuclear matrix targeting signal and associates with histone deacetylase 3 in nuclear speckles, Differentiation, 72, 8, 2004. Crossref
-
Hendzel Michael J, Kruhlak Michael J, MacLean Natalie A.B, Boisvert F.-Michel, Lever Melody A, Bazett-Jones David P, Compartmentalization of regulatory proteins in the cell nucleus, The Journal of Steroid Biochemistry and Molecular Biology, 76, 1-5, 2001. Crossref
-
Chen Hai-Bin, Human papillomavirus 16 E6 is associated with the nuclear matrix of esophageal carcinoma cells, World Journal of Gastroenterology, 7, 6, 2001. Crossref
-
Zaidi Sayyed K., Fritz Andrew J., Tracy Kirsten M., Gordon Jonathan A., Tye Coralee E., Boyd Joseph, Van Wijnen Andre J., Nickerson Jeffrey A., Imbalzano Antony N., Lian Jane B., Stein Janet L., Stein Gary S., Nuclear organization mediates cancer-compromised genetic and epigenetic control, Advances in Biological Regulation, 69, 2018. Crossref
-
Graham J. Dinny, Hanson Adrienne R., Croft Amanda J., Fox Archa H., Clarke Christine L., Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci, The FASEB Journal, 23, 2, 2009. Crossref
-
Meier Iris, Subnuclear Trafficking and the Nuclear Matrix, in Nuclear Import and Export in Plants and Animals, 2005. Crossref
-
De Bosscher K., Vanden Berghe W., Haegeman G., Regulation of NF-кB by Glucocorticoids, in Nuclear Factor кB, 2003. Crossref
-
De Bosscher Karolien, Vanden Berghe Wim, Haegeman Guy, The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression, Endocrine Reviews, 24, 4, 2003. Crossref
-
Mazaira Gisela I., Echeverria Pablo C., Galigniana Mario D., Nucleocytoplasmic shuttling of the glucocorticoid receptor is influenced by tetratricopeptide repeat-containing proteins, Journal of Cell Science, 2020. Crossref
-
Zaidi S. Kaleem, Javed Amjad, Choi Je-Yong, van Wijnen André J., Stein Janet L., Lian Jane B., Stein Gary S., A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene, Journal of Cell Science, 114, 17, 2001. Crossref
-
Kimura Yukio, Sakai Fumie, Nakano Osami, Kisaki Osamu, Sugimoto Hiroaki, Sawamura Takashi, Sadano Hiroyuki, Osumi Takashi, The Newly Identified Human Nuclear Protein NXP-2 Possesses Three Distinct Domains, the Nuclear Matrix-binding, RNA-binding, and Coiled-coil Domains, Journal of Biological Chemistry, 277, 23, 2002. Crossref
-
Barseguian Karina, Lutterbach Bart, Hiebert Scott W., Nickerson Jeffrey, Lian Jane B., Stein Janet L., van Wijnen Andre J., Stein Gary S., Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins, Proceedings of the National Academy of Sciences, 99, 24, 2002. Crossref
-
De Bosscher K, Vanden Berghe W, Haegeman G, Cross-talk between nuclear receptors and nuclear factor κB, Oncogene, 25, 51, 2006. Crossref
-
Zaidi Sayyed K., Sullivan Andrew J., van Wijnen Andre J., Stein Janet L., Stein Gary S., Lian Jane B., Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites, Proceedings of the National Academy of Sciences, 99, 12, 2002. Crossref