Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Cell Nucleus in Context
SINOPSIS
The molecular pathways that participate in regulation of gene expression are being progressively unraveled. Extracellular signals, including the binding of extracellular matrix and soluble molecules to cell membrane receptors, activate specific signal transducers that process information inside the cell leading to alteration in gene expression. Some of these transducers when translocated to the cell nucleus may bind to transcription complexes and thereby modify the transcriptional activity of specific genes. However, the basic molecules involved in the regulation of gene expression are found in many different cell and tissue types; thus, the mechanisms underlying tissue-specific gene expression are still obscure.
In this review we focus on the study of signals that are conveyed to the nucleus. We propose that the way in which extracellular signals are integrated may account for tissue-specific gene expression. We argue that the integration of signals depends on the nature of the structural organization of cells (i.e., extracellular matrix, membrane proteins, cytoskeleton, nucleus) that defines a particular cell type within a tissue. Thus, gene expression can be envisioned as being regulated by the mutual influence of extracellular and intracellular organizations, i.e., in context.
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Plachot Cedric, Lelièvre Sophie A, DNA methylation control of tissue polarity and cellular differentiation in the mammary epithelium, Experimental Cell Research, 298, 1, 2004. Crossref
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Kaminker Patrick, Plachot Cedric, Kim Sahn-Ho, Chung Peter, Crippen Danielle, Petersen Ole W., Bissell Mina J., Campisi Judith, Lelièvre Sophie A., Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2, Journal of Cell Science, 118, 6, 2005. Crossref
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Lelièvre Sophie A., Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control, Biochimica et Biophysica Acta (BBA) - General Subjects, 1790, 9, 2009. Crossref
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Schmeichel Karen L., Bissell Mina J., Modeling tissue-specific signaling and organ function in three dimensions, Journal of Cell Science, 116, 12, 2003. Crossref
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Long Fuhui, Peng Hanchuan, Sudar Damir, Lelièvre Sophie A, Knowles David W, Phenotype clustering of breast epithelial cells in confocal images based on nuclear protein distribution analysis, BMC Cell Biology, 8, S1, 2007. Crossref
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Knowles David W., Sudar Damir, Bator-Kelly Carol, Bissell Mina J., Lelièvre Sophie A., Automated local bright feature image analysis of nuclear protein distribution identifies changes in tissue phenotype, Proceedings of the National Academy of Sciences, 103, 12, 2006. Crossref