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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v16.i2.40
pages 155-170

Cellular Genetics of Host Susceptibility and Resistance to Virus Infection

Donald H. Rubin
Research Medicine, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212; Department of Medicine, Division of Infectious Diseases; and Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232
H. Earl Ruley
Vanderbilt University School of Medicine


Viruses are obligate intracellular parasites that rely upon the host cell for activities essential to their life cycles. Gene-trap mutagenesis provides a rapid, genome-wide strategy to identify candidate cellular genes required for virus replication. The candidate genes provide a starting point for mechanistic studies of cellular processes that participate in the virus life cycle and may provide targets for novel antiviral therapies.

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