Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 2.156 Factor de Impacto de 5 años: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Volumes:
Volumen 30, 2020 Volumen 29, 2019 Volumen 28, 2018 Volumen 27, 2017 Volumen 26, 2016 Volumen 25, 2015 Volumen 24, 2014 Volumen 23, 2013 Volumen 22, 2012 Volumen 21, 2011 Volumen 20, 2010 Volumen 19, 2009 Volumen 18, 2008 Volumen 17, 2007 Volumen 16, 2006 Volumen 15, 2005 Volumen 14, 2004 Volumen 13, 2003 Volumen 12, 2002 Volumen 11, 2001 Volumen 10, 2000 Volumen 9, 1999 Volumen 8, 1998 Volumen 7, 1997 Volumen 6, 1996 Volumen 5, 1995 Volumen 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i2.10
pages 89-106

Nuclear Import and Export: Transport Factors, Mechanisms and Regulation

Junona Moroianu
Laboratory of Cell Biology, Rockefeller University, New York, NY 10021

SINOPSIS

Molecules enter and exit the nucleus of eukaryotic cells through aqueous channels formed in the nuclear envelope by nuclear pore complexes (NPC). Proteins entering or leaving the nucleus use nuclear localization signals (NLSs), or nuclear export signals (NESs), respectively. Different types of NLSs and NESs are specifically recognized directly, or indirectly via adapters, by transport receptors. In recent years, many transport receptors, adapters, and the specific cargoes they carry into or out of the nucleus have been identified, revealing an increasing level of complexity. All the transport receptors identified are members of the same family and have in common the ability to shuttle between the nucleus and cytoplasm, and to interact with RanGTP and with nucleoporins at the NPC. The GTPase Ran regulates the interaction between receptors and cargoes, or adapters, and is crucial in providing directionality to nuclear import and export. One of the challenges for the future will be establishing the mechanisms of translocation through the NPC of receptors together with their cargoes. Nuclear import and export of many cargoes is regulated. The molecular mechanisms of regulation of nucleocytoplasmic transport during cell growth, development, viral infections, and different diseases constitute important areas of investigation.


Articles with similar content:

Lamins and Lamin-Binding Proteins in Functional Chromatin Organization
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Josef Gotzmann , Roland Foisner
Nuclear Matrix Targeting of Steroid Receptors: Specific Signal Sequences and Acceptor Proteins
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Donald B. DeFranco, Jennifer Guerrero
The Nuclear Pore Complex: Structure, Function, and Dynamics
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Martin W. Goldberg, Elena M. Kiseleva, Janet Cronshaw, Terence D. Allen
CREB-Mediated Transcriptional Control
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 1
Ourania M. Andrisani
Nuclear Transport of Steroid Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 1
Leonard C. Shank, Bryce M. Paschal