Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Sp1 Control of Gene Expression in Myeloid Cells
SINOPSIS
Gene transcription plays a critical role in the differentiation of myeloid cells. However, there is no single, master regulator of all myeloid genes. Rather, myeloid gene transcription is regulated by the combinatorial effects of a limited number of key transcription factors. Sp1 is a powerful activator of gene transcription in many cell types. Although it is wildly expressed, Sp1 binds and activates the promoters of a large number of important myeloid genes. This presents the paradox of how a widely expressed transcription factor can regulate lineage-specific gene transcription. This review discusses the structure, function, and expression patterns of Sp1 and its related Sp family members. Illustrative examples of the tissue-specific regulation of myeloid target genes are presented. The roles of post-translational modifications of Sp1, alterations in target gene chromatin structure, and important cooperating transcription factors are discussed. Thus, Sp1 serves as a model of how a widely expressed transcription factor regulates the expression of tissue-specific genes.
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Koga Tomoaki, Suico Mary Ann, Nakamura Hideaki, Taura Manabu, Lu Zhuo, Shuto Tsuyoshi, Okiyoneda Tsukasa, Kai Hirofumi, Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells, FEBS Letters, 579, 13, 2005. Crossref
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Suico Mary Ann, Koga Tomoaki, Shuto Tsuyoshi, Hisatsune Akinori, Lu Zhuo, Basbaum Carol, Okiyoneda Tsukasa, Kai Hirofumi, Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells, Biochemical and Biophysical Research Communications, 324, 4, 2004. Crossref
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McAllister John J., Dahiya Satinder, Berman Rachel, Collins Mackenzie, Nonnemacher Michael R., Burdo Tricia H., Wigdahl Brian, Altered recruitment of Sp isoforms to HIV-1 long terminal repeat between differentiated monoblastic cell lines and primary monocyte-derived macrophages, Frontiers in Virology, 2, 2022. Crossref