Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Regulation, Regulatory Activities, and Function of Biglycan
SINOPSIS
Biglycan is a member of the small leucine repeat proteoglycan family (SLRP). The biglycan gene is located on the X chromosome. Based on the amino acid sequence, the protein core of biglycan can be divided into six distinct domains: (1) a signal sequence, (2) a propeptide region, (3) a N-terminal glycosaminoglycan attachment region, (4) a cysteine loop, followed by (5) a leucine- rich repeat region domain (that makes up over 66% of the core protein), and (6) a final cysteine loop. Biglycan has been found in almost every organ within our body, but it is not uniformly distributed within an organ. Biglycan has been shown to be expressed on the cell surface, pericellularly, and sometimes within the extracellular matrices of a range of specialized cell types within the organ. Its expression pattern has been shown to be altered by growth factors and certain pathologic conditions. The regulation of biglycan expression occurs by both transcriptional and nontranscriptional mechanisms. The currently proposed biglycan functions appear to be dependent on the particular microenvironment and on the organ in question. In this review, we will focus on gene and protein structure, localization, expression, regulation, and function.
-
Lamoureux François, Baud'huin Marc, Duplomb Laurence, Heymann Dominique, Rédini Françoise, Proteoglycans: key partners in bone cell biology, BioEssays, 29, 8, 2007. Crossref
-
Ungefroren Hendrik, Groth Stephanie, Fändrich Fred, Antioxidants and inhibitors of flavoprotein-dependent oxidases abrogate TGF-beta induction of biglycan: Evidence for a role of reactive oxygen species, Signal Transduction, 6, 5, 2006. Crossref
-
Lechner Beatrice E., Lim Jae H., Mercado Mary Lynn, Fallon Justin R., Developmental regulation of biglycan expression in muscle and tendon, Muscle & Nerve, 34, 3, 2006. Crossref
-
Bi Yanming, Nielsen Karina L., Kilts Tina M., Yoon Anne, A. Karsdal Morten, Wimer Helen F., Greenfield Edward M., Heegaard Anne-Marie, Young Marian F., Biglycan deficiency increases osteoclast differentiation and activity due to defective osteoblasts, Bone, 38, 6, 2006. Crossref
-
Brandan Enrique, Cabello-Verrugio Claudio, Vial Cecilia, Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy, Matrix Biology, 27, 8, 2008. Crossref
-
Calmus Megan L, Macksoud Elyse E, Tucker Richard, Iozzo Renato V, Lechner Beatrice E, A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin, REPRODUCTION, 142, 1, 2011. Crossref
-
Ly Mellisa, Laremore Tatiana N., Linhardt Robert J., Proteoglycomics: Recent Progress and Future Challenges, OMICS: A Journal of Integrative Biology, 14, 4, 2010. Crossref
-
Wadhwa Sunil, Bi Yanming, Ortiz Ana T., Embree Mildred C., Kilts Tina, Iozzo Renato, Opperman Lynne A., Young Marian F., Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice, Bone, 40, 4, 2007. Crossref
-
Prabhakar Vikas, Sasisekharan Ram, The Biosynthesis and Catabolism of Galactosaminoglycans, in Chondroitin Sulfate: Structure, Role and Pharmacological Activity, 53, 2006. Crossref
-
Rizell S., Barrenas M.-L., Andlin-Sobocki A., Stecksen-Blicks C., Kjellberg H., 45,X/46,XX karyotype mitigates the aberrant craniofacial morphology in Turner syndrome, The European Journal of Orthodontics, 35, 4, 2013. Crossref
-
Xing Xiaojing, Gu Xiaohu, Ma Tianfei, Ye Huinan, Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancer, Tumor Biology, 36, 3, 2015. Crossref
-
Nahid Payam, Bliven-Sizemore Erin, Jarlsberg Leah G., De Groote Mary A., Johnson John L., Muzanyi Grace, Engle Melissa, Weiner Marc, Janjic Nebojsa, Sterling David G., Ochsner Urs A., Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis, Tuberculosis, 94, 3, 2014. Crossref
-
Shawky Michael S., Ricciardelli Carmela, Lord Megan, Whitelock John, Ferro Vito, Britt Kara, Thompson Erik W., Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk, Journal of Mammary Gland Biology and Neoplasia, 20, 3-4, 2015. Crossref
-
Sun Hengzi, Wang Xiang, Zhang Yifang, Che Xiaoxia, Liu Zhiming, Zhang Lili, Qiu Chunping, Lv Qingtao, Jiang Jie, Biglycan enhances the ability of migration and invasion in endometrial cancer, Archives of Gynecology and Obstetrics, 293, 2, 2016. Crossref
-
Xu L., Li Z., Liu S.-Y., Xu S.-Y., Ni G.-X., Asporin and osteoarthritis, Osteoarthritis and Cartilage, 23, 6, 2015. Crossref
-
Ren Hui, Liang De, Jiang Xiaobing, Tang Jingjing, Cui Jianchao, Wei Qiushi, Zhang Shuncong, Yao Zhensong, Shen Gengyang, Lin Shunxin, Variance of spinal osteoporosis induced by dexamethasone and methylprednisolone and its associated mechanism, Steroids, 102, 2015. Crossref
-
Maris Pamela, Blomme Arnaud, Palacios Ana Perez, Costanza Brunella, Bellahcène Akeila, Bianchi Elettra, Gofflot Stephanie, Drion Pierre, Trombino Giovanna Elvi, Di Valentin Emmanuel, Cusumano Pino G., Maweja Sylvie, Jerusalem Guy, Delvenne Philippe, Lifrange Eric, Castronovo Vincent, Turtoi Andrei, Kemp Christopher, Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer, PLOS Medicine, 12, 9, 2015. Crossref
-
XING XIAOJING, GU XIAOHU, MA TIANFEI, Knockdown of biglycan expression by RNA interference inhibits the proliferation and invasion of, and induces apoptosis in, the HCT116 colon cancer cell line, Molecular Medicine Reports, 12, 5, 2015. Crossref
-
Wu Zhiping, Aron Abraham W., Macksoud Elyse E., Iozzo Renato V., Hai Chi-Ming, Lechner Beatrice E., Rameshwar Pranela, Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition, PLoS ONE, 7, 1, 2012. Crossref
-
Nastase Madalina V., Young Marian F., Schaefer Liliana, Biglycan, Journal of Histochemistry & Cytochemistry, 60, 12, 2012. Crossref
-
Ibrahim I., Serrano M.J., Ruest L.B., Svoboda K.K.H., Biglycan and Decorin Expression and Distribution in Palatal Adhesion, Journal of Dental Research, 96, 12, 2017. Crossref
-
Chang Chenbei, Agonists and Antagonists of TGF-β Family Ligands, Cold Spring Harbor Perspectives in Biology, 8, 8, 2016. Crossref
-
Chen Sujuan, Guo Dandan, Zhang Wei, Xie Yunfei, Yang Haijie, Cheng Binfeng, Wang Lei, Yang Rui, Bi Jiajia, Feng Zhiwei, Biglycan, a Nitric Oxide-Downregulated Proteoglycan, Prevents Nitric Oxide-Induced Neuronal Cell Apoptosis via Targeting Erk1/2 and p38 Signaling Pathways, Journal of Molecular Neuroscience, 66, 1, 2018. Crossref
-
da Silva Ludmila B., Menezes Milene C., Kitano Eduardo S., Oliveira Ana K., Abreu Afonso G., Souza Gisele O., Heinemann Marcos B., Isaac Lourdes, Fraga Tatiana R., Serrano Solange M. T., Barbosa Angela S., Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host, Frontiers in Cellular and Infection Microbiology, 8, 2018. Crossref
-
Zhao Sirguleng, Tao Li, Tian Yunyun, Tai Dapeng, Liu Pengxia, Liu Dongjun, Isolation and characterization of ovine umbilical cord-derived mesenchymal stem cells, Cytotechnology, 71, 1, 2019. Crossref
-
Ungefroren Hendrik, TGF-β Signaling and Biglycan in Pancreatic Cancer, in Transforming Growth Factor-β in Cancer Therapy, Volume II, 2008. Crossref
-
Listik Eduardo, Azevedo Marques Gaschler Juliana, Matias Murilo, Neuppmann Feres Murilo Fernando, Toma Leny, Raphaelli Nahás-Scocate Ana Carla, Proteoglycans and dental biology: the first review, Carbohydrate Polymers, 225, 2019. Crossref
-
Hu Lei, Duan Yan-tao, Li Jian-fang, Su Li-ping, Yan Min, Zhu Zheng-gang, Liu Bing-ya, Yang Qiu-meng, Biglycan enhances gastric cancer invasion by activating FAK signaling pathway, Oncotarget, 5, 7, 2014. Crossref
-
Yeh Shan-Ju, Chang Chien-An, Li Cheng-Wei, Wang Lily Hui-Ching, Chen Bor-Sen, Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification, Oncotarget, 10, 38, 2019. Crossref
-
Nie Kechao, Shi Laner, Wen Yi, Pan Jinglin, Li Peiwu, Zheng Zhihua, Liu Fengbin, Identification of hub genes correlated with the pathogenesis and prognosis of gastric cancer via bioinformatics methods, Minerva Medica, 111, 3, 2020. Crossref
-
Tzanakakis George, Giatagana Eirini-Maria, Kuskov Andrey, Berdiaki Aikaterini, Tsatsakis Aristidis, Neagu Monica, Nikitovic Dragana, Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors, Cancers, 12, 9, 2020. Crossref
-
Lowry William E., Blanpain Cedric, Nowak Jonathan A., Guasch Geraldine, Lewis Lisa, Fuchs Elaine, Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells, Genes & Development, 19, 13, 2005. Crossref
-
Groth Stephanie, Schulze Maren, Kalthoff Holger, Fändrich Fred, Ungefroren Hendrik, Adhesion and Rac1-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-β, Journal of Biological Chemistry, 280, 39, 2005. Crossref
-
Veronez Alexandre, Pires Letícia Albertini, de Aro Andrea Aparecida, do Amaral Maria Esméria Corezola, Marretto Esquisatto Marcelo Augusto, Effect of exercising in water on the fibrocartilage of the deep digital flexor tendon in rats with induced diabetes, Tissue and Cell, 76, 2022. Crossref