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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2013007781
pages 339-354

XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis

Chuan Liu
Department of Oncology, Changhai Hospital, Second Military Medical University, P.R.China
Qinghua Yin
Department of Oncology, the First People's Hospital of Yueyang, P.R.China
Lian Li
Yueyang Second People's Hospital, 263 Baling Road, Yueyang, People's Republic of China, 414000
Guangjun Jiao
Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing, P.R. China
Mei Wang
Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, People's Republic of China, 200433
Yajie Wang
Department of Oncology, Changhai Hospital, Second Military Medical University, P.R.China

SINOPSIS

The XRCC1 Arg194Trp and Arg280His polymorphisms were likely to be involved with the development of bladder cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science for relevant articles with a time limit of April 25, 2013. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the two polymorphisms and bladder cancer susceptibility using a random-effects model. This meta-analysis including 14 case-control studies evaluated the associations between the two XRCC1 polymorphisms and bladder cancer susceptibility. Overall, for Arg194Trp, significant associations were found in TT versus CC (OR = 1.78, 95% CI = 1.12−2.82) and the recessive model (OR = 1.71, 95% CI = 1.11−2.65); for Arg280His, significant associations were also found in AG versus GG (OR = 1.63, 95% CI = 1.24−2.13) and the dominant model (OR = 1.39, 95% CI = 1.07−1.82). When stratified by ethnicity, in Asian population, significant associations were found for Arg194Trp polymorphism in TT versus CC (OR = 2.99, 95% CI = 1.48−6.06), the dominant model (OR = 1.33, 95% CI = 1.03−1.72) and the recessive model (OR = 2.72, 95% CI = 1.36−5.45), and for Arg280His in GA versus GG (OR = 2.13, 95% CI = 1.63−2.97), but no significant associations were found in no-Asian population. This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.