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Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Aberrant Regulation of Alternative Pre-mRNA Splicing in Hepatocellular Carcinoma

Volumen 24, Edición 2, 2014, pp. 133-149
DOI: 10.1615/CritRevEukaryotGeneExpr.2014007702
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SINOPSIS

Alternative splicing of precursors messenger RNA (pre-mRNA) is commonly used to increase the diversity of messenger RNAs expressed by the genome in normal multicellular organisms. Dysregulation of alternative splicing underlies a number of human diseases, including cancers. Increasing evidence supports the important role of this expansive layer of gene regulation in hepatocarcinogenesis. Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide because of its aggressive property and limited therapeutic options. Studies suggest that aberrant alternative splicing promotes generation of oncogenic variants in HCC, whereas tumor suppressors are self-inactivated by aberrant alternative splicing in HCC. Moreover, different spliced variants of the same gene can display distinct and even antagonistic biological functions in HCC. As a result, inhibiting the splicing of oncogenic variants and the self-inactivation of tumor suppressors are likely to be new therapy strategies. This review provides a perspective of the emerging evidence of both alternative splicing as a critical mechanism for the development of HCC and that potential cross-talk through signaling pathways among different variants might aid in the development of novel molecular targets of HCC.

CITADO POR
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  2. Krivtsova Olga, Makarova Anna, Lazarevich Natalia, Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma, World Journal of Hepatology, 10, 10, 2018. Crossref

  3. Jin Young-Joo, Byun Seyoun, Han Seonggyun, Chamberlin John, Kim Dongwook, Kim Min Jung, Lee Younghee, Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors, BMC Medical Genomics, 12, S8, 2019. Crossref

  4. Liu Lijuan, Liu Youyi, Chen Xiaobei, Wang Miao, Zhou Yan, Zhou Ping, Li Wenxin, Zhu Fan, Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma, Oncotarget, 8, 27, 2017. Crossref

  5. Yosudjai Juthamas , Wongkham Sopit , Jirawatnotai Siwanon , Kaewkong Worasak , Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Review), Biomedical Reports, 2019. Crossref

  6. Wu Panyisha, Zhang Moya, Webster Nicholas J. G., Alternative RNA Splicing in Fatty Liver Disease, Frontiers in Endocrinology, 12, 2021. Crossref

  7. Xu Rui-Yao, Ding Zhan, Zhao Qing, Ke Tiao-Ying, Chen Shu, Wang Xing-Yu, Wang Yao-Yun, Sheng Meng-Fei, Wang Wei, Long Ni, Shen Yu-Xian, Xu Yong-Zhen, Shao Wei, An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma, Genes, 13, 4, 2022. Crossref

  8. Shaglouf Laila H. Faraj, Ranjpour Maryam, Wajid Saima, Tandon Rakesh, Vasudevan Karisangal Ramaswamy, Jain Swatantra Kumar, Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways, Protoplasma, 2022. Crossref

  9. Lu Yu, Ren Xuechen, Zhou Chengliang, Chen Hao, Fan Yong, Wang Chen, Overexpression of Ribosomal Protein S6 Kinase A4 (RPS6KA4) Predicts a Poor Prognosis in Hepatocellular Carcinoma Patients: A Study Based on TCGA Samples, Combinatorial Chemistry & High Throughput Screening, 25, 13, 2022. Crossref

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