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Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Imprimir: 0278-940X
ISSN En Línea: 1943-619X

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Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v28.i34.60
pages 383-387

Absorbable Mesh Aids in Development of Discrete, Tissue-Engineered Constructs

K. J. L. Burg
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
C. R. Culberson
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
K. G. Greene
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
A. B. Loebsack
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
W. R. Roland
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
W. D. Holder, Jr.
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
C. R. Halberstadt
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861
R. J. Beiler
Department of General Surgery Research, Carolinas Medical Center, P. 0. Box 32861, Charlotte, NC 28232-2861

SINOPSIS

Absorbable mesh was investigated as a potential containment material in which to house discrete, small, tissue-engineered constructs. The mesh was fashioned into bags of varying shapes and consistent volumes. Cells were cultivated on porous, collagen beads, and the tissue constructs were placed into the bags. The mechanical integrity of the bags and feasibility of the design was tested in vitro. The bags successfully maintained their integrity as the cells developed on the collagen matrices. Furthermore, their porosity allowed access of nutrients and waste products to and from the developing tissue. Having demonstrated feasibility of processing, the next step is to optimize the cell culture specifications and materials design.


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